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Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
DC Field | Value | Language |
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dc.contributor.author | 임선경 | - |
dc.contributor.author | 황성순 | - |
dc.date.accessioned | 2019-02-14T01:53:44Z | - |
dc.date.available | 2019-02-14T01:53:44Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1738-6055 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167279 | - |
dc.description.abstract | Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre-loxP system is widely used as an integral experimental tool for generating the conditional. This system has enabled researchers to investigate genes of interest in a tissue/cell (spatial control) and/or time (temporal control) specific manner. A various tissue-specific Cre-driver mouse lines have been generated to date, and new Cre lines are still being developed. This review provides a brief overview of Cre-loxP system and a few commonly used promoters for expression of tissue-specific Cre recombinase. Also, we finally introduce some available links to the Web sites that provides detailed information about Cre mouse lines including their characterization. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 한국실험동물학회 | - |
dc.relation.isPartOf | Laboratory Animal Research | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Hyeonhui Kim | - |
dc.contributor.googleauthor | Minki Kim | - |
dc.contributor.googleauthor | Sun-Kyoung Im | - |
dc.contributor.googleauthor | Sungsoon Fang | - |
dc.identifier.doi | 10.5625/lar.2018.34.4.147 | - |
dc.contributor.localId | A05684 | - |
dc.contributor.localId | A05443 | - |
dc.relation.journalcode | J02149 | - |
dc.identifier.eissn | 2233-7660 | - |
dc.identifier.pmid | 30671100 | - |
dc.subject.keyword | Cre portal sites | - |
dc.subject.keyword | Cre-loxP system | - |
dc.subject.keyword | tissue specific promoter | - |
dc.contributor.alternativeName | Im, Sun-Kyoung | - |
dc.contributor.affiliatedAuthor | 임선경 | - |
dc.contributor.affiliatedAuthor | 황성순 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 147 | - |
dc.citation.endPage | 159 | - |
dc.identifier.bibliographicCitation | Laboratory Animal Research, Vol.34(4) : 147-159, 2018 | - |
dc.identifier.rimsid | 61483 | - |
dc.type.rims | ART | - |
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