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Spatial Organization of Superparamagnetic Iron Oxide Nanoparticles in/on Nano/Microsized Carriers Modulates the Magnetic Resonance Signal

Authors
 Min Kyung Lee  ;  Nicholas E. Clay  ;  Eunkyung Ko  ;  Cartney E. Smith  ;  Lin Chen  ;  Nicholas Cho  ;  Hak-Joon Sung  ;  Luisa DiPietro  ;  Jonghwi Lee  ;  Hyunjoon Kong 
Citation
 LANGMUIR, Vol.34(50) : 15276-15282, 2018 
Journal Title
LANGMUIR
ISSN
 0743-7463 
Issue Date
2018
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) are often encapsulated into drug-carrying nano/microsized particles for simultaneous magnetic resonance (MR) imaging and treatment of diseased tissues. Unfortunately, encapsulated SPIONs may have a limited ability to modulate the T2-weighted relaxation of water protons, but this insight has not been examined systematically. This study demonstrates that SPIONs immobilized on 200 nm diameter poly(lactic- co-glycolic acid) (PLGA) nanoparticles using Pickering emulsification present 18-fold higher relaxivity than encapsulated SPIONs and 1.5-fold higher relaxivity than free SPIONs. In contrast, the SPIONs immobilized on 10 μm diameter PLGA particles exhibit a minor increase in MR relaxivity. This interesting finding will significantly impact current efforts to synthesize and assemble advanced MR contrast agents.
Full Text
https://pubs.acs.org/doi/10.1021/acs.langmuir.8b01477
DOI
10.1021/acs.langmuir.8b01477
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167264
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