Cited 6 times in
Spatial Organization of Superparamagnetic Iron Oxide Nanoparticles in/on Nano/Microsized Carriers Modulates the Magnetic Resonance Signal
DC Field | Value | Language |
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dc.contributor.author | 성학준 | - |
dc.date.accessioned | 2019-02-14T01:51:59Z | - |
dc.date.available | 2019-02-14T01:51:59Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0743-7463 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167264 | - |
dc.description.abstract | Superparamagnetic iron oxide nanoparticles (SPIONs) are often encapsulated into drug-carrying nano/microsized particles for simultaneous magnetic resonance (MR) imaging and treatment of diseased tissues. Unfortunately, encapsulated SPIONs may have a limited ability to modulate the T2-weighted relaxation of water protons, but this insight has not been examined systematically. This study demonstrates that SPIONs immobilized on 200 nm diameter poly(lactic- co-glycolic acid) (PLGA) nanoparticles using Pickering emulsification present 18-fold higher relaxivity than encapsulated SPIONs and 1.5-fold higher relaxivity than free SPIONs. In contrast, the SPIONs immobilized on 10 μm diameter PLGA particles exhibit a minor increase in MR relaxivity. This interesting finding will significantly impact current efforts to synthesize and assemble advanced MR contrast agents. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | LANGMUIR | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Spatial Organization of Superparamagnetic Iron Oxide Nanoparticles in/on Nano/Microsized Carriers Modulates the Magnetic Resonance Signal | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.googleauthor | Min Kyung Lee | - |
dc.contributor.googleauthor | Nicholas E. Clay | - |
dc.contributor.googleauthor | Eunkyung Ko | - |
dc.contributor.googleauthor | Cartney E. Smith | - |
dc.contributor.googleauthor | Lin Chen | - |
dc.contributor.googleauthor | Nicholas Cho | - |
dc.contributor.googleauthor | Hak-Joon Sung | - |
dc.contributor.googleauthor | Luisa DiPietro | - |
dc.contributor.googleauthor | Jonghwi Lee | - |
dc.contributor.googleauthor | Hyunjoon Kong | - |
dc.identifier.doi | 10.1021/acs.langmuir.8b01477 | - |
dc.contributor.localId | A01958 | - |
dc.relation.journalcode | J02155 | - |
dc.identifier.eissn | 1520-5827 | - |
dc.identifier.pmid | 30458616 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acs.langmuir.8b01477 | - |
dc.contributor.alternativeName | Sung, Hak-Joon | - |
dc.contributor.affiliatedAuthor | 성학준 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 50 | - |
dc.citation.startPage | 15276 | - |
dc.citation.endPage | 15282 | - |
dc.identifier.bibliographicCitation | LANGMUIR, Vol.34(50) : 15276-15282, 2018 | - |
dc.identifier.rimsid | 61468 | - |
dc.type.rims | ART | - |
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