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Phase 2 Study of an Intravenous Busulfan and Melphalan Conditioning Regimen for Autologous Stem Cell Transplantation in Patients with Multiple Myeloma (KMM150)

Authors
 Sung-Hoon Jung  ;  Je-Jung Lee  ;  Jin Seok Kim  ;  Chang-Ki Min  ;  Kihyun Kim  ;  Yunsuk Choi  ;  Hyeon-Seok Eom  ;  Young Don Joo  ;  Sung-Hyun Kim  ;  Jae-Yong Kwak  ;  Hye Jin Kang  ;  Jae Hoon Lee  ;  Ho Sup Lee  ;  Yeung-Chul Mun  ;  Joon Ho Moon  ;  Sang Kyun Sohn  ;  Seong Kyu Park  ;  Yong Park  ;  Ho-Jin Shin  ;  Sung-Soo Yoon 
Citation
 BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol.24(5) : 923-929, 2018 
Journal Title
 BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 
ISSN
 1083-8791 
Issue Date
2018
Keywords
Autologous transplantation ; Intravenous busulfan ; Melphalan ; Multiple myeloma
Abstract
This prospective study evaluated the efficacy and toxicity of intravenous busulfan and melphalan as a conditioning regimen for autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM). A total of 99 patients with MM, enrolled between January 2013 and March 2016, received intravenous busulfan (9.6 mg/kg) and melphalan (140 mg/m2) before ASCT. The median time to transplant was 6.2 months, and 90 (90.9%) patients underwent ASCT within 12 months of the diagnosis. The overall response rate after ASCT was 94.0%, including 43.5% with a stringent complete response/complete response, 27.3% with very good partial response, and 23.2% with partial response. The most common severe nonhematologic toxicity (grade 3 to 4) was infection (26.3%) and stomatitis (15.2%). Three (3.2%) patients developed veno-occlusive disease. No treatment-related mortality was observed. After a median follow-up of 26.1 months, the median progression-free survival was 27.2 months (range, 13.0 to 41.4 months) and median overall survival was not reached. In conclusion, a conditioning regimen of intravenous busulfan and melphalan was effective and tolerable. ClinicalTrials.gov. number: NCT01923935.
Full Text
https://www.sciencedirect.com/science/article/pii/S1083879118300193
DOI
10.1016/j.bbmt.2018.01.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167250
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