Cited 8 times in
Phase 2 Study of an Intravenous Busulfan and Melphalan Conditioning Regimen for Autologous Stem Cell Transplantation in Patients with Multiple Myeloma (KMM150)
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.date.accessioned | 2019-02-14T01:50:56Z | - |
dc.date.available | 2019-02-14T01:50:56Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1083-8791 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167250 | - |
dc.description.abstract | This prospective study evaluated the efficacy and toxicity of intravenous busulfan and melphalan as a conditioning regimen for autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM). A total of 99 patients with MM, enrolled between January 2013 and March 2016, received intravenous busulfan (9.6 mg/kg) and melphalan (140 mg/m2) before ASCT. The median time to transplant was 6.2 months, and 90 (90.9%) patients underwent ASCT within 12 months of the diagnosis. The overall response rate after ASCT was 94.0%, including 43.5% with a stringent complete response/complete response, 27.3% with very good partial response, and 23.2% with partial response. The most common severe nonhematologic toxicity (grade 3 to 4) was infection (26.3%) and stomatitis (15.2%). Three (3.2%) patients developed veno-occlusive disease. No treatment-related mortality was observed. After a median follow-up of 26.1 months, the median progression-free survival was 27.2 months (range, 13.0 to 41.4 months) and median overall survival was not reached. In conclusion, a conditioning regimen of intravenous busulfan and melphalan was effective and tolerable. ClinicalTrials.gov. number: NCT01923935. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Carden Jennings Publishing | - |
dc.relation.isPartOf | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Phase 2 Study of an Intravenous Busulfan and Melphalan Conditioning Regimen for Autologous Stem Cell Transplantation in Patients with Multiple Myeloma (KMM150) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung-Hoon Jung | - |
dc.contributor.googleauthor | Je-Jung Lee | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Chang-Ki Min | - |
dc.contributor.googleauthor | Kihyun Kim | - |
dc.contributor.googleauthor | Yunsuk Choi | - |
dc.contributor.googleauthor | Hyeon-Seok Eom | - |
dc.contributor.googleauthor | Young Don Joo | - |
dc.contributor.googleauthor | Sung-Hyun Kim | - |
dc.contributor.googleauthor | Jae-Yong Kwak | - |
dc.contributor.googleauthor | Hye Jin Kang | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Ho Sup Lee | - |
dc.contributor.googleauthor | Yeung-Chul Mun | - |
dc.contributor.googleauthor | Joon Ho Moon | - |
dc.contributor.googleauthor | Sang Kyun Sohn | - |
dc.contributor.googleauthor | Seong Kyu Park | - |
dc.contributor.googleauthor | Yong Park | - |
dc.contributor.googleauthor | Ho-Jin Shin | - |
dc.contributor.googleauthor | Sung-Soo Yoon | - |
dc.identifier.doi | 10.1016/j.bbmt.2018.01.004 | - |
dc.contributor.localId | A01017 | - |
dc.relation.journalcode | J00308 | - |
dc.identifier.eissn | 1523-6536 | - |
dc.identifier.pmid | 29339269 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1083879118300193 | - |
dc.subject.keyword | Autologous transplantation | - |
dc.subject.keyword | Intravenous busulfan | - |
dc.subject.keyword | Melphalan | - |
dc.subject.keyword | Multiple myeloma | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | 김진석 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 923 | - |
dc.citation.endPage | 929 | - |
dc.identifier.bibliographicCitation | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol.24(5) : 923-929, 2018 | - |
dc.identifier.rimsid | 61455 | - |
dc.type.rims | ART | - |
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