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자가면역용혈환자에서 항-Fya 동종항체에 의한 급성용혈성수혈반응 1예

Other Titles
 Case of Acute Hemolytic Transfusion Reaction due to Anti-Fya Alloantibody in a Patient with Autoimmune Hemolytic Anemia 
 최승준  ;  나현진  ;  김윤덕  ;  김신영  ;  김현옥 
 Korean Journal of Blood Transfusion (대한수혈학회지), Vol.29(3) : 320-327, 2018 
Journal Title
 Korean Journal of Blood Transfusion (대한수혈학회지) 
Issue Date
Acute hemolytic transfusion reaction ; Autoantibody ; Alloantibody ; Panagglutination ; Duffy blood group
A 72-year-old man with general weakness visited the outpatient clinic of the hematology department. The patient had been treated under the diagnosis of autoimmune hemolytic anemia for 2 years. His hemoglobin level at the time of the visit was 6.3 g/dL, and a blood transfusion was requested to treat his anemia. The patient’s blood type was A, RhD positive. Antibody screening and identification test showed agglutination in all reagent cells with a positive reaction to autologous red blood cells (RBCs). He had a prior transfusion history with three least incompatible RBCs. The patient returned home after receiving one unit of leukoreduced filtered RBC, which was the least incompatible blood in the crossmatching test. After approximately five hours, however, fever, chills, dyspnea, abdominal pain, and hematuria appeared and the patient returned to the emergency room next day after the transfusion. The anti-Fya antibody, which was masked by the autoantibody, was identified after autoadsorption using polyethylene glycol. He was diagnosed with an acute hemolytic transfusion reaction due to anti-Fya that had not been detected before the transfusion. In this setting, it is necessary to consider the identification of coexisting alloantibodies in patients with autoantibodies and to become more familiar with the method of autoantibody adsorption.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김신영(Kim, Sin Young) ORCID logo https://orcid.org/0000-0002-2609-8945
김윤덕(Kim, Yun Deok) ORCID logo https://orcid.org/0000-0002-5336-7936
김현옥(Kim, Hyun Ok) ORCID logo https://orcid.org/0000-0002-4964-1963
최승준(Choi, Seung Jun) ORCID logo https://orcid.org/0000-0003-0736-1055
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