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Stroke Severity in Patients on Non-Vitamin K Antagonist Oral Anticoagulants with a Standard or Insufficient Dose

DC FieldValueLanguage
dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author박형종-
dc.contributor.author이경열-
dc.contributor.author이혜선-
dc.contributor.author허지회-
dc.date.accessioned2019-01-15T17:01:19Z-
dc.date.available2019-01-15T17:01:19Z-
dc.date.issued2018-
dc.identifier.issn0340-6245-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166763-
dc.description.abstractBACKGROUND:  The stroke severity or functional outcomes could differ because the efficacy of non-vitamin K antagonist oral anticoagulants (NOACs) could be different according to the dose. We investigated whether there was any difference in the stroke outcomes in patients with non-valvular atrial fibrillation (NVAF) by their prior medication status, including standard-dosed versus under-dosed NOACs. MATERIALS AND METHODS:  We enrolled 858 patients with acute ischaemic stroke with chronic NVAF admitted at six hospitals in Korea. We categorized their prior medication status as follows: (1) no anti-thrombotics (n = 219), (2) only anti-platelet (n = 347), (3) warfarin with a sub-therapeutic intensity (n = 185), (4) warfarin with a therapeutic intensity (n = 37), (5) under-dosed NOAC (n = 27) and (6) standard-dosed NOAC (n = 43). We compared the initial stroke severity between groups. RESULTS:  Among the 858 patients, the patients on standard-dosed NOACs had the lowest initial National Institute of Health Stroke Scale (NIHSS) score, followed by those on warfarin with a therapeutic intensity and those on only anti-platelet (p < 0.05). Multivariate analysis demonstrated that the NIHSS score was significantly low in the patients on warfarin with a therapeutic intensity (B, -5.602; 95% confidence interval [CI], -8.636 to -2.568; p < 0.001) or those on standard-dosed NOACs (B, -3.588; 95% CI, -6.405 to -0.771; p = 0.013), while there was no difference in the NIHSS score between the patients not taking any anti-thrombotics and those on warfarin with a sub-therapeutic intensity or under-dosed NOACs. CONCLUSION:  Use of warfarin with a therapeutic intensity or standard-dosed NOACs was associated with a relatively mild stroke in the patients with NVAF.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish, French(Summary), German(Summary)-
dc.publisherSchattauer-
dc.relation.isPartOfTHROMBOSIS AND HAEMOSTASIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleStroke Severity in Patients on Non-Vitamin K Antagonist Oral Anticoagulants with a Standard or Insufficient Dose-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorYo Han Jung-
dc.contributor.googleauthorHye-Yeon Choi-
dc.contributor.googleauthorKyung-Yul Lee-
dc.contributor.googleauthorKyeongyeol Cheon-
dc.contributor.googleauthorSang Won Han-
dc.contributor.googleauthorJoong Hyun Park-
dc.contributor.googleauthorHan-Jin Cho-
dc.contributor.googleauthorHyung Jong Park-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorJi Hoe Heo-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorYoung Dae Kim-
dc.identifier.doi10.1055/s-0038-1675602-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA01273-
dc.contributor.localIdA05600-
dc.contributor.localIdA05600-
dc.contributor.localIdA02648-
dc.contributor.localIdA02648-
dc.contributor.localIdA03312-
dc.contributor.localIdA03312-
dc.contributor.localIdA04369-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ02726-
dc.identifier.pmid30453351-
dc.identifier.urlhttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1675602-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor박형종-
dc.contributor.affiliatedAuthor박형종-
dc.contributor.affiliatedAuthor이경열-
dc.contributor.affiliatedAuthor이경열-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor허지회-
dc.contributor.affiliatedAuthor허지회-
dc.citation.volume118-
dc.citation.number12-
dc.citation.startPage2145-
dc.citation.endPage2151-
dc.identifier.bibliographicCitationTHROMBOSIS AND HAEMOSTASIS, Vol.118(12) : 2145-2151, 2018-
dc.identifier.rimsid58031-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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