Cited 14 times in
Stroke Severity in Patients on Non-Vitamin K Antagonist Oral Anticoagulants with a Standard or Insufficient Dose
DC Field | Value | Language |
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dc.contributor.author | 김영대 | - |
dc.contributor.author | 남효석 | - |
dc.contributor.author | 박형종 | - |
dc.contributor.author | 이경열 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2019-01-15T17:01:19Z | - |
dc.date.available | 2019-01-15T17:01:19Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0340-6245 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166763 | - |
dc.description.abstract | BACKGROUND: The stroke severity or functional outcomes could differ because the efficacy of non-vitamin K antagonist oral anticoagulants (NOACs) could be different according to the dose. We investigated whether there was any difference in the stroke outcomes in patients with non-valvular atrial fibrillation (NVAF) by their prior medication status, including standard-dosed versus under-dosed NOACs. MATERIALS AND METHODS: We enrolled 858 patients with acute ischaemic stroke with chronic NVAF admitted at six hospitals in Korea. We categorized their prior medication status as follows: (1) no anti-thrombotics (n = 219), (2) only anti-platelet (n = 347), (3) warfarin with a sub-therapeutic intensity (n = 185), (4) warfarin with a therapeutic intensity (n = 37), (5) under-dosed NOAC (n = 27) and (6) standard-dosed NOAC (n = 43). We compared the initial stroke severity between groups. RESULTS: Among the 858 patients, the patients on standard-dosed NOACs had the lowest initial National Institute of Health Stroke Scale (NIHSS) score, followed by those on warfarin with a therapeutic intensity and those on only anti-platelet (p < 0.05). Multivariate analysis demonstrated that the NIHSS score was significantly low in the patients on warfarin with a therapeutic intensity (B, -5.602; 95% confidence interval [CI], -8.636 to -2.568; p < 0.001) or those on standard-dosed NOACs (B, -3.588; 95% CI, -6.405 to -0.771; p = 0.013), while there was no difference in the NIHSS score between the patients not taking any anti-thrombotics and those on warfarin with a sub-therapeutic intensity or under-dosed NOACs. CONCLUSION: Use of warfarin with a therapeutic intensity or standard-dosed NOACs was associated with a relatively mild stroke in the patients with NVAF. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English, French(Summary), German(Summary) | - |
dc.publisher | Schattauer | - |
dc.relation.isPartOf | THROMBOSIS AND HAEMOSTASIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Stroke Severity in Patients on Non-Vitamin K Antagonist Oral Anticoagulants with a Standard or Insufficient Dose | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Yo Han Jung | - |
dc.contributor.googleauthor | Hye-Yeon Choi | - |
dc.contributor.googleauthor | Kyung-Yul Lee | - |
dc.contributor.googleauthor | Kyeongyeol Cheon | - |
dc.contributor.googleauthor | Sang Won Han | - |
dc.contributor.googleauthor | Joong Hyun Park | - |
dc.contributor.googleauthor | Han-Jin Cho | - |
dc.contributor.googleauthor | Hyung Jong Park | - |
dc.contributor.googleauthor | Hyo Suk Nam | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Young Dae Kim | - |
dc.identifier.doi | 10.1055/s-0038-1675602 | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A05600 | - |
dc.contributor.localId | A02648 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J02726 | - |
dc.identifier.pmid | 30453351 | - |
dc.identifier.url | https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1675602 | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | 김영대 | - |
dc.contributor.affiliatedAuthor | 남효석 | - |
dc.contributor.affiliatedAuthor | 박형종 | - |
dc.contributor.affiliatedAuthor | 이경열 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 허지회 | - |
dc.citation.volume | 118 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2145 | - |
dc.citation.endPage | 2151 | - |
dc.identifier.bibliographicCitation | THROMBOSIS AND HAEMOSTASIS, Vol.118(12) : 2145-2151, 2018 | - |
dc.identifier.rimsid | 58031 | - |
dc.type.rims | ART | - |
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