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Application of metabolomics in prediction of lymph node metastasis in papillary thyroid carcinoma

Other Titles
 대사체학을 이용한 갑상선 유두암의 림프절 전이 예측 
Authors
 서지원 
Department
 Dept. of Radiology (영상의학교실) 
Degree
박사
Issue Date
2018
Description
의학과/박사
Abstract
Purpose: The aim of this study was to find useful metabolites to predict lymph node (LN) metastasis in patients with papillary thyroid cancer (PTC) through a metabolomics approach and investigate the potential role of metabolites as a novel prognostic marker. Materials and methods: Fifty-two consecutive patients (median age: 41.5 years, range 15-74 years) were enrolled who underwent total thyroidectomy and central LN dissection with or without lateral LN dissection in Severance Hospital between October 2013 and July 2015. The study specimens were provided by the Severance Hospital Gene Bank, and consisted of PTC from each patient. The specimens were prepared for proton nuclear magnetic resonance (1H-NMR) spectroscopy. Spectral data by 1H-NMR spectroscopy were acquired, processed, and analyzed. Patients were grouped in three ways, according to the presence of LN metastasis, central LN metastasis and lateral LN metastasis. Chi-square test and the student t-test were used to analyze categorical variables and continuous variables, respectively. The Mann-Whitney U test was used for univariate analysis of metabolites. Orthogonal projections to latent structure discriminant analysis (OPLS-DA) was used for multivariate analysis to discriminate metabolic differences between the two groups. Results: Among 52 patients, 32 had central LN metastasis and 19 had lateral LN metastasis. No clinical or histopathological characteristic was significantly different for all comparisons. On univariate analysis, no metabolite showed significant difference for all comparisons. On multivariate analysis, OPLS-DA did not discriminate the presence and absence of LN metastasis. Lactate was found to be the most promising metabolite. Conclusion: No metabolite could discriminate the presence of LN metastasis. However, lactate was found to be the most promising metabolite for discrimination. Further studies with larger sample sizes are needed to elucidate significant metabolites which can indicate the presence of LN metastasis in patients with PTC.
Files in This Item:
T014946.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 3. Dissertation
Yonsei Authors
Seo, Ji Won(서지원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166433
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