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Extensive disease subtypes in adult patients with ulcerative colitis : outcomes and predicting factors

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 성인의 광범위 궤양성 대장염(E3)의 새로운 분류와 그 결과 및 예측요인 
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Background and Aim: There are few comparative studies between pancolitis and non-pancolitis E3 in adult patients with ulcerative colitis (UC). The aim of this study was to evaluate the natural disease courses and factors affecting outcomes between pancolitis and non-pancolitis E3. Methods:We retrospectively analyzed 117 patients, including 93 with extensive colitis (E3) and 24 with UC confined to the rectum or left-sided colon and appendiceal orifice inflammation at the time of diagnosis who were regularly followed-up for at least 1 year. Patients with E3 were divided into two groups according to disease extension degree: pancolitis group (disease extent up to the cecumor proximal ascending colon) and non-pancolitis E3 group (disease extent above the splenic flexure but not up to the proximal ascending colon). Clinical findings at diagnosis; comorbidity; medications; Mayo score; cumulative rates of corticosteroid, immunomodulator, and anti-tumor necrosis factor (anti-TNF) alpha use; relapse; and admission were compared between thepancolitis and nonpancolitis E3 groups. Results: The median follow-up duration of the 117 patients was 74 (15–158) months. Fifty-one patients (43.5%) had pancolitis. The Mayo score at initial diagnosis, cumulative relapse rate, and cumulative admission rate were significantly higher in the pancolitis group than in the non-pancolitis E3 group (P<0.001, P=0.023, P=0.007, respectively). However, there was no significant differencebetween the two groups in the rates of cumulative immunomodulator and anti-TNF alpha use (P=0.67and0.73, respectively). Conclusions: Of extensive UC (E3), pancolitis was associated with higher probabilities of cumulative relapse or admission, indicatingpoor prognosis.
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