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Extensive disease subtypes in adult patients with ulcerative colitis : outcomes and predicting factors
DC Field | Value | Language |
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dc.contributor.author | 신동석 | - |
dc.date.accessioned | 2019-01-02T16:44:46Z | - |
dc.date.available | 2019-01-02T16:44:46Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166407 | - |
dc.description | 의과대학원 | - |
dc.description.abstract | Background and Aim: There are few comparative studies between pancolitis and non-pancolitis E3 in adult patients with ulcerative colitis (UC). The aim of this study was to evaluate the natural disease courses and factors affecting outcomes between pancolitis and non-pancolitis E3. Methods:We retrospectively analyzed 117 patients, including 93 with extensive colitis (E3) and 24 with UC confined to the rectum or left-sided colon and appendiceal orifice inflammation at the time of diagnosis who were regularly followed-up for at least 1 year. Patients with E3 were divided into two groups according to disease extension degree: pancolitis group (disease extent up to the cecumor proximal ascending colon) and non-pancolitis E3 group (disease extent above the splenic flexure but not up to the proximal ascending colon). Clinical findings at diagnosis; comorbidity; medications; Mayo score; cumulative rates of corticosteroid, immunomodulator, and anti-tumor necrosis factor (anti-TNF) alpha use; relapse; and admission were compared between thepancolitis and nonpancolitis E3 groups. Results: The median follow-up duration of the 117 patients was 74 (15–158) months. Fifty-one patients (43.5%) had pancolitis. The Mayo score at initial diagnosis, cumulative relapse rate, and cumulative admission rate were significantly higher in the pancolitis group than in the non-pancolitis E3 group (P<0.001, P=0.023, P=0.007, respectively). However, there was no significant differencebetween the two groups in the rates of cumulative immunomodulator and anti-TNF alpha use (P=0.67and0.73, respectively). Conclusions: Of extensive UC (E3), pancolitis was associated with higher probabilities of cumulative relapse or admission, indicatingpoor prognosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | 연세대학교 | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Extensive disease subtypes in adult patients with ulcerative colitis : outcomes and predicting factors | - |
dc.title.alternative | 성인의 광범위 궤양성 대장염(E3)의 새로운 분류와 그 결과 및 예측요인 | - |
dc.type | Thesis | - |
dc.description.degree | 석사 | - |
dc.contributor.alternativeName | Shin, Dong Suk | - |
dc.type.local | Thesis | - |
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