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Design of Polymeric Culture Substrates to Promote Proangiogenic Potential of Stem Cells

 Byeong‐Ju Kwon  ;  Xintong Wang  ;  Mi‐Lan Kang  ;  Jin You  ;  Shin‐Jeong Lee  ;  Won Shik Kim  ;  Young‐sup Yoon  ;  Jong‐Chul Park  ;  Hak‐Joon Sung 
 MACROMOLECULAR BIOSCIENCE, Vol.18(2) : 1700340, 2018 
Journal Title
Issue Date
Stem cells are a promising cell source for regenerative medicine due to their differentiation and self-renewal capacities. In the field of regenerative medicine and tissue engineering, a variety of biomedical technologies have been tested to improve proangiogenic activities of stem cells. However, their therapeutic effect is found to be limited in the clinic because of cell loss, senescence, and insufficient therapeutic activities. To address this type of issue, advanced techniques for biomaterial synthesis and fabrication have been approached to mimic proangiogenic microenvironment and to direct proangiogenic activities. This review highlights the types of polymers and design strategies that have been studied to promote proangiogenic activities of stem cells. In particular, scaffolds, hydrogels, and surface topographies, as well as insight into their underlying mechanisms to improve proangiogenic activities are the focuses. The strategy to promote angiogenic activities of hMSCs by controlling substrate repellency is introduced, and the future direction is proposed
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kwon, Byeong-Ju(권병주) ORCID logo https://orcid.org/0000-0001-9916-0546
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
Yoon, Young Sup(윤영섭)
Lee, Shin-Jeong(이신정) ORCID logo https://orcid.org/0000-0002-0780-0559
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