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단일 3차 의료 기관의 약물 유발 아나필락시스 발생 현황

Other Titles
 Drug-Induced Anaphylaxis in a Single Korean Tertiary Hospital 
 문일주  ;  박혜정  ;  김성렬  ;  고범석  ;  임동우  ;  박경희  ;  이재현  ;  박중원 
 Korean Journal of Medicine, Vol.88(3) : 281-287, 2015 
Journal Title
 Korean Journal of Medicine 
Issue Date
Anaphylaxis ; Epidemiology ; Epinephrine ; Adverse drug reaction
Background/Aims: Drug-induced anaphylaxis (DIA) is a severe, acute, and potentially life-threatening condition. In Korea, only a few well-documented cases of DIA have been described. Therefore, the aim of this study was to investigate the clinical characteristics, causes, and management of DIA in a single Korean medical institute. Methods: This was a retrospective medical record review of all DIA patients who visited the in-patient, out-patient, and emergency departments of our hospital from January 1 2006 to October 30 2013. Results: Among 605 cases of anaphylaxis, 167 were drug-induced. The culprit drugs were contrast agents (43 cases, 25.7%), antibiotics (38, 22.8%), non-steroidal anti-inflammatory drugs (35, 21.0%), anti-cancer drugs (22, 13.2%), parenteral vitamins (9, 5.4%), ranitidine (6, 3.6%), and neuromuscular blockers (3, 1.8%). The most common organ-specific symptoms/signs were cardiovascular (74.3%), cutaneous (71.3%), respiratory (55.7%), and gastrointestinal manifestations (19.2%). In most cases, DIA was treated with antihistamines (77.2%) and systemic corticosteroids (76.5%); the use of epinephrine was considerably less frequent (35.3%). Conclusions: In our institution, contrast agents were the leading cause of DIA. Although epinephrine is the drug of choice in the treatment of acute anaphylaxis, fewer than 50% of the study patients received epinephrine to treat DIA.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
고범석(Koh, Beom Seok)
김성렬(Kim, Sung Ryeol) ORCID logo https://orcid.org/0000-0001-7418-0049
문일주(Moon, Il Joo)
박경희(Park, Kyung Hee) ORCID logo https://orcid.org/0000-0003-3605-5364
박중원(Park, Jung Won) ORCID logo https://orcid.org/0000-0003-0249-8749
박혜정(Park, Hye Jung) ORCID logo https://orcid.org/0000-0002-1862-1003
이재현(Lee, Jae Hyun) ORCID logo https://orcid.org/0000-0002-0760-0071
임동우(Leem, Dong Woo)
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