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Extranodal natural killer/T-cell lymphoma from skin or soft tissue: suggestion of treatment from multinational retrospective analysis.

 H. K. Ahn  ;  C. Suh  ;  S. S. Chuang  ;  J. Suzumiya  ;  Y. H. Ko  ;  S. J. Kim  ;  J. R. Huh  ;  D. H. Yoon  ;  S. Y. Oh  ;  J. S. Kim  ;  S. I. Lee  ;  K. W. Park  ;  P. P. Hsieh  ;  S. Nakamura  ;  T. Yoshino  ;  K. Ito  ;  T. Nagatani  ;  K. Oshimi  ;  R. Suzuki  ;  W. S. Kim 
 Annals of Oncology, Vol.23(10) : 2703-2707, 2012 
Journal Title
 Annals of Oncology 
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Killer Cells, Natural/immunology* ; Lymphoma, T-Cell/immunology* ; Lymphoma, T-Cell/therapy ; Male ; Middle Aged ; Retrospective Studies ; Skin Neoplasms/immunology* ; Skin Neoplasms/therapy ; Soft Tissue Neoplasms/immunology* ; Soft Tissue Neoplasms/therapy ; Young Adult
chemotherapy ; extranodal NK/T-cell lymphoma ; prognosis ; skin ; radiation therapy
BACKGROUND: Clinical features and outcomes of extranodal natural killer/T-cell lymphoma (ENKL) arising from extranasal sites are not fully understood. The purpose of this study was to study the prognosis and treatment outcome of skin/soft tissue primary ENKL. PATIENTS AND METHODS: This multicenter retrospective study included 48 patients with skin/soft tissue primary ENKL diagnosed from 1993 to 2010. RESULTS: Patients with Ann Arbor stage I, T1-2N0M0 by International Society for Cutaneous Lymphomas-European Organization of Research and Treatment of Cancer TNM (tumour-node-metastasis) stage, International prognostic index score of 0-1, and a Korean prognostic index (KPI) score of 0-1 were associated with better survival. Four of five patients with T1-2N0M0 disease achieved complete response with radiation alone. In disseminated disease, only 6 of 13 patients responded to anthracycline-containing chemotherapy, and all the two patients receiving SMILE showed response. CONCLUSION: In conclusion, we identified the prognostic value of KPI, and we suggest a treatment recommendation according to the TNM (tumour-node-metastasis) stage. Radiotherapy with/without chemotherapy seemed to be optimal in localized disease. In advanced stages, a more aggressive treatment regimen with newer agents should be sought.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
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