Cited 10 times in
Aptamer-Modified Magnetic Nanosensitizer for In Vivo MR Imaging of HER2-Expressing Cancer
DC Field | Value | Language |
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dc.contributor.author | 구민희 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 허단 | - |
dc.date.accessioned | 2018-11-23T10:50:32Z | - |
dc.date.available | 2018-11-23T10:50:32Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1931-7573 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165763 | - |
dc.description.abstract | The aim of this study was the development of a human epidermal growth factor receptor 2 (HER2)-targetable contrast agent for magnetic resonance imaging (MRI) with a high magnetic sensitivity. An anti-HER2 aptamer-modified magnetic nanosensitizer (AptHER2-MNS) was prepared by conjugation with 5'-thiol-modified aptamers and maleimidylated magnetic nanocrystals (MNCs). The physicochemical characteristics and targeting ability of AptHER2-MNS were confirmed, and the binding affinity (Kd) onto HER2 protein of AptHER2-MNS was 0.57 ± 0.26 nM. In vivo MRI contrast enhancement ability was also verified at HER2+ cancer cell (NIH3T6.7)-xenograft mouse models (n = 3) at 3T clinical MRI instrument. The control experiment was carried out using non-labeled MNCs. The results indicated that up to 150% contrast enhancement was achieved at the tumor region in the T2-weighted MR images after the injection of the AptHER2-MNS agent in mice that received the NIH3T6.7 cells. | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | NANOSCALE RESEARCH LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Aptamer-Modified Magnetic Nanosensitizer for In Vivo MR Imaging of HER2-Expressing Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Dan Heo | - |
dc.contributor.googleauthor | Minhee Ku | - |
dc.contributor.googleauthor | Jung-Hoon Kim | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.identifier.doi | 10.1186/s11671-018-2682-3 | - |
dc.contributor.localId | A00191 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A04346 | - |
dc.relation.journalcode | J02286 | - |
dc.identifier.eissn | 1556-276X | - |
dc.identifier.pmid | 30229394 | - |
dc.identifier.url | https://link.springer.com/article/10.1186/s11671-018-2682-3 | - |
dc.subject.keyword | Aptamer | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Contrast agent | - |
dc.subject.keyword | HER2 | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Molecular imaging | - |
dc.contributor.alternativeName | Ku, Min Hee | - |
dc.contributor.affiliatedAuthor | 구민희 | - |
dc.contributor.affiliatedAuthor | 서진석 | - |
dc.contributor.affiliatedAuthor | 양재문 | - |
dc.contributor.affiliatedAuthor | 허단 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 288 | - |
dc.identifier.bibliographicCitation | NANOSCALE RESEARCH LETTERS, Vol.13(1) : 288, 2018 | - |
dc.identifier.rimsid | 60343 | - |
dc.type.rims | ART | - |
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