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Dynamic Susceptibility Contrast (DSC) Perfusion MR in the Prediction of Long-Term Survival of Glioblastomas (GBM): Correlation with MGMT Promoter Methylation and 1p/19q Deletions

 Yong Wonn Kwon  ;  Won-Jin Moon  ;  Mina Park  ;  Hong Gee Roh  ;  Young Cho Koh  ;  Sang Woo Song  ;  Jin Woo Choi 
 Investigative Magnetic Resonance Imaging, Vol.22 : 158-167, 2018 
Journal Title
Investigative Magnetic Resonance Imaging
Issue Date
Purpose: To investigate the surgical, perfusion, and molecular characteristics of glioblastomas
which influence long-term survival after treatment, and to explore the association between
MR perfusion parameters and the presence of MGMT methylation and 1p/19q deletions.
Materials and Methods: This retrospective study was approved by our institutional review
board. A total 43 patients were included, all with pathologic diagnosis of glioblastoma with
known MGMT methylation and 1p/19q deletion statuses. We divided these patients into longterm
(≥ 60 months, n = 7) and short-term (< 60 months, n = 36) survivors, then compared
surgical extent, molecular status, and rCBV parameters between the two groups using
Fisher’s exact test or Mann-Whitney test. The rCBV parameters were analyzed according to
the presence of MGMT methylation and 1p/19q deletions. We investigated the relationship
between the mean rCBV and overall survival using linear correlation. Multivariable linear
regression was performed in order to find the variables related to overall survival.
Results: Long-term survivors (100% [7 of 7]) demonstrated a greater percentage of gross
total or near total resection than short-term survivors (54.5% [18 of 33]). A higher prevalence
of 1p/19q deletions was also noted among the long-term survivors (42.9% [3 of 7]) than the
short-term survivors (0.0% [0 of 36]). The rCBV parameters did not differ between the longterm
and short-term survivors. The rCBV values were marginally lower in patients with MGMT
methylation and 1p/19q deletions. Despite no correlation found between overall survival and
rCBV in the whole group, the short-term survivor group showed negative correlation (R2 = 0.181,
P = 0.025). Multivariable linear regression revealed that surgical extent and 1p/19q deletions,
but not rCBV values, were associated with prolonged overall survival.
Conclusion: While preoperative rCBV and 1p/19q deletion status are related to each other,
only surgical extent and the presence of 1p/19q deletion in GBM patients may predict longterm
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Park, Mina(박미나) ORCID logo https://orcid.org/0000-0002-2005-7560
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