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Can radial bone mineral density predict spinal bone mineral density in patients with advanced Duchenne muscular dystrophy?

Authors
 Eunyoung Kim  ;  Han Eol Cho  ;  Ji Ho Jung  ;  Jang Woo Lee  ;  Won Ah Choi  ;  Seong-Woong Kang 
Citation
 Medicine, Vol.97(40) : e12303, 2018 
Journal Title
 Medicine 
ISSN
 0025-7974 
Issue Date
2018
MeSH
Absorptiometry, Photon/statistics & numerical data* ; Adult ; Bone Density* ; Female ; Humans ; Male ; Muscular Dystrophy, Duchenne/complications ; Muscular Dystrophy, Duchenne/diagnostic imaging* ; Osteoporosis/diagnostic imaging* ; Osteoporosis/etiology ; Osteoporotic Fractures/diagnostic imaging ; Osteoporotic Fractures/etiology ; Predictive Value of Tests ; Radius/diagnostic imaging* ; Retrospective Studies ; Risk Assessment/methods ; Sensitivity and Specificity ; Spine/diagnostic imaging* ; Young Adult
Keywords
bone mineral density ; dual X-ray absorptiometry ; Duchenne muscular dystrophy ; osteoporosis
Abstract
In advanced Duchenne muscular dystrophy (DMD), patients with high bone fracture risk due to osteoporosis, it is difficult to measure spinal bone mineral density (BMD) because of maintaining proper posture. This study began with the idea that if we diagnose and manage osteoporosis by predicting spinal BMD through easily testable radial BMD, we could prevent fracture and improve quality of life in DMD patients. In 61 DMD patients aged 20 years or older who were admitted to Gangnam Severance Hospital from April 2013 to May 2015, radial BMD and spinal BMD were measured to compare their Z-scores. In 45 patients, the z-score was less than -2.0 in spinal BMD defined as osteoporosis. And the optimal range of Z-score in the radius was -5.2 to -5.0 (sensitivity 78.9%, specificity 71.4%). Only through the radius BMD, spinal BMD can be predicted and we suggest appropriate times for treatments.
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DOI
10.1097/MD.0000000000012303
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
강성웅(Kang, Seong Woong) ORCID logo https://orcid.org/0000-0002-7279-3893
김은영(Kim, Eun Young) ORCID logo https://orcid.org/0000-0001-6622-219X
최원아(Choi, Won Ah) ORCID logo https://orcid.org/0000-0003-0403-8869
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165551
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