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Resting-state fMRI reveals network disintegration during delirium

Authors
 Simone J.T. van Montfort  ;  Edwin van Dellen  ;  Aletta M.R. van den Bosch  ;  Willem M. Otte  ;  Maya J.L. Schutte  ;  Soo-Hee Choi  ;  Tae-Sub Chung  ;  Sunghyon Kyeong  ;  Arjen J.C. Slooter  ;  Jae-Jin Kim 
Citation
 NEUROIMAGE-CLINICAL, Vol.20 : 35-41, 2018 
Journal Title
 NEUROIMAGE-CLINICAL 
Issue Date
2018
Keywords
Brain networks ; Delirium ; Functional connectivity ; Minimum spanning tree ; Resting-state ; fMRI
Abstract
Delirium is characterized by inattention and other cognitive deficits, symptoms that have been associated with disturbed interactions between remote brain regions. Recent EEG studies confirm that disturbed global network topology may underlie the syndrome, but lack an anatomical basis. The aim of this study was to increase our understanding of the global organization of functional connectivity during delirium and to localize possible alterations. Resting-state fMRI data from 44 subjects were analyzed, and motion-free data were available in nine delirious patients, seven post delirium patients and thirteen non-delirious clinical controls. We focused on the functional network backbones using the minimum spanning tree, which allows unbiased network comparisons. During delirium a longer diameter (mean (M) = 0.30, standard deviation (SD) = 0.05, P = .024) and a lower leaf fraction (M = 0.32, SD = 0.03, P = .027) was found compared to the control group (M = 0.28, SD = 0.04 respectively M = 0.35, SD = 0.03), suggesting reduced functional network integration and efficiency. Delirium duration was strongly related to loss of network hierarchy (rho = -0.92, P = .001). Connectivity strength was decreased in the post delirium group (M = 0.16, SD = 0.01) compared to the delirium group (M = 0.17, SD = 0.03, P = .024) and the control group (M = 0.19, SD = 0.02, P = .001). Permutation tests revealed a decreased degree of the right posterior cingulate cortex during delirium and complex regional alterations after delirium. These findings indicate that delirium reflects disintegration of functional interactions between remote brain areas and suggest long-term impact after the syndrome resolves.
Files in This Item:
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DOI
10.1016/j.nicl.2018.06.024
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Chung, Tae Sub(정태섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165431
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