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Serum CYR61 Is Associated with Disease Activity in Graves' Orbitopathy

Authors
 Young Jun Woo  ;  Yuri Seo  ;  Jin Joo Kim  ;  Ji Won Kim  ;  Yil Park  ;  Jin Sook Yoon 
Citation
 Ocular Immunology and Inflammation, Vol.26(7) : 1094-1100, 2018 
Journal Title
 Ocular Immunology and Inflammation 
ISSN
 0927-3948 
Issue Date
2018
Keywords
Biomarker ; CCN1 ; CYR61 ; inflammation ; thyroid ophthalmopathy
Abstract
PURPOSE: To investigate the clinical implications of cysteine-rich angiogenic inducer 61 (CYR61) in Graves' orbitopathy (GO). METHODS: Sera from 52 GO patients, 23 Graves' disease (GD) patients, and 20 healthy controls, and orbital fat tissue samples from 12 of 52 GO patients and 8 control subjects were included for analysis. Concentrations of CYR61 were measured from sera with an enzyme-linked immunosorbent assay, and CYR61 mRNA expression levels were evaluated from orbital fat tissue with polymerase chain reaction. RESULTS: Serum CYR61 levels were higher in GO patients than in controls (p = 0.001). Patients with active GO showed higher CYR61 levels than those with inactive GO (p < 0.001) or GD (p = 0.004). Expression of CYR61 mRNA was 7.4-fold higher in patients with GO than in healthy controls (p < 0.001). CONCLUSIONS: CYR61 could be an adjuvant biomarker associated with the inflammatory activity of GO.
Full Text
https://www.tandfonline.com/doi/full/10.1080/09273948.2017.1319960
DOI
10.1080/09273948.2017.1319960
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
윤진숙(Yoon, Jin Sook) ORCID logo https://orcid.org/0000-0002-8751-9467
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165372
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