Cited 10 times in
Serum CYR61 Is Associated with Disease Activity in Graves' Orbitopathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤진숙 | - |
dc.date.accessioned | 2018-11-16T16:49:55Z | - |
dc.date.available | 2018-11-16T16:49:55Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0927-3948 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165372 | - |
dc.description.abstract | PURPOSE: To investigate the clinical implications of cysteine-rich angiogenic inducer 61 (CYR61) in Graves' orbitopathy (GO). METHODS: Sera from 52 GO patients, 23 Graves' disease (GD) patients, and 20 healthy controls, and orbital fat tissue samples from 12 of 52 GO patients and 8 control subjects were included for analysis. Concentrations of CYR61 were measured from sera with an enzyme-linked immunosorbent assay, and CYR61 mRNA expression levels were evaluated from orbital fat tissue with polymerase chain reaction. RESULTS: Serum CYR61 levels were higher in GO patients than in controls (p = 0.001). Patients with active GO showed higher CYR61 levels than those with inactive GO (p < 0.001) or GD (p = 0.004). Expression of CYR61 mRNA was 7.4-fold higher in patients with GO than in healthy controls (p < 0.001). CONCLUSIONS: CYR61 could be an adjuvant biomarker associated with the inflammatory activity of GO. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | OCULAR IMMUNOLOGY AND INFLAMMATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Serum CYR61 Is Associated with Disease Activity in Graves' Orbitopathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Young Jun Woo | - |
dc.contributor.googleauthor | Yuri Seo | - |
dc.contributor.googleauthor | Jin Joo Kim | - |
dc.contributor.googleauthor | Ji Won Kim | - |
dc.contributor.googleauthor | Yil Park | - |
dc.contributor.googleauthor | Jin Sook Yoon | - |
dc.identifier.doi | 10.1080/09273948.2017.1319960 | - |
dc.contributor.localId | A02611 | - |
dc.relation.journalcode | J03485 | - |
dc.identifier.eissn | 1744-5078 | - |
dc.identifier.pmid | 28548552 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/09273948.2017.1319960 | - |
dc.subject.keyword | Biomarker | - |
dc.subject.keyword | CCN1 | - |
dc.subject.keyword | CYR61 | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | thyroid ophthalmopathy | - |
dc.contributor.alternativeName | Yoon, Jin Sook | - |
dc.contributor.affiliatedAuthor | 윤진숙 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1094 | - |
dc.citation.endPage | 1100 | - |
dc.identifier.bibliographicCitation | OCULAR IMMUNOLOGY AND INFLAMMATION, Vol.26(7) : 1094-1100, 2018 | - |
dc.identifier.rimsid | 58783 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.