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Prognoses and Clinical Outcomes of Primary and Recurrent Uveal Melanoma.

 Jee Hung Kim  ;  Su-Jin Shin  ;  Soo Jin Heo  ;  Eun-Ah Choe  ;  Chang Gon Kim  ;  Minkyu Jung  ;  Ki Chang Keum  ;  Jin Sook Yoon  ;  Sung Chul Lee  ;  Sang Joon Shin 
 Cancer Research and Treatment, Vol.50(4) : 1238-1251, 2018 
Journal Title
 Cancer Research and Treatment 
Issue Date
BAP1 ; Melanoma ; Prognosis ; Recurrence ; Survival ; Uveal neoplasm
PURPOSE: Uveal melanoma has a very poor prognosis despite successful local primary tumor treatment. In this study, we investigated prognostic factors that more accurately reflected the likelihood ofrecurrence and survival and delineated a prognostic model that could effectively identify different risk groups based on initial clinical parameters. Materials and Methods: Prognostic factors associated with distant recurrence, recurrence-free survival (RFS), progression-free survival, and overall survival from distant recurrence to death (OS2) were analyzed in 226 patients with stage I-III uveal melanoma who underwent primary local therapy. RESULTS: Forty-nine patients (21.7%) had distant recurrences, which occurred most frequently in the liver (87.7%). In a multivariate analysis, local radiotherapy improved RFS among patients with multiple recurrence risk factors relative to excision (not reached vs. 19.0 months, p=0.004). Patients with BRCA1-associated protein-1 (BAP1)‒negative primary tumors showed a longer RFS duration after primary treatments, while those with BAP1-negative metastatic tissues had a shorter OS2 compared to those with BAP1-positive tumors, both not statistically insignificance (RFS: not reached vs. 82.0 months, p=0.258; OS2: 15.7 vs. 24.4 months, p=0.216). Male sex (hazard ratio [HR], 3.79; p=0.012), a short RFS (HR, 4.89; p=0.014), and a largest metastatic tumor linear diameter ≥ 45 mm (HR, 5.48; p=0.017) were found to correlate with worse post-recurrence survival. CONCLUSION: Risk factors could be used to classify uveal melanoma cases and subsequently direct individual treatment strategies. Furthermore, metastasectomy appears to contribute to improved survival outcomes.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, Jee Hung(김지형) ORCID logo https://orcid.org/0000-0002-9044-8540
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Jung, Min Kyu(정민규) ORCID logo https://orcid.org/0000-0001-8281-3387
Choe, Eun Ah(최은아) ORCID logo https://orcid.org/0000-0001-7700-8711
Heo, Su Jin(허수진) ORCID logo https://orcid.org/0000-0002-0615-5869
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