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Prognoses and Clinical Outcomes of Primary and Recurrent Uveal Melanoma.

 Jee Hung Kim  ;  Su-Jin Shin  ;  Soo Jin Heo  ;  Eun-Ah Choe  ;  Chang Gon Kim  ;  Minkyu Jung  ;  Ki Chang Keum  ;  Jin Sook Yoon  ;  Sung Chul Lee  ;  Sang Joon Shin 
 Cancer Research and Treatment, Vol.50(4) : 1238-1251, 2018 
Journal Title
 Cancer Research and Treatment 
Issue Date
BAP1 ; Melanoma ; Prognosis ; Recurrence ; Survival ; Uveal neoplasm
PURPOSE: Uveal melanoma has a very poor prognosis despite successful local primary tumor treatment. In this study, we investigated prognostic factors that more accurately reflected the likelihood ofrecurrence and survival and delineated a prognostic model that could effectively identify different risk groups based on initial clinical parameters. Materials and Methods: Prognostic factors associated with distant recurrence, recurrence-free survival (RFS), progression-free survival, and overall survival from distant recurrence to death (OS2) were analyzed in 226 patients with stage I-III uveal melanoma who underwent primary local therapy. RESULTS: Forty-nine patients (21.7%) had distant recurrences, which occurred most frequently in the liver (87.7%). In a multivariate analysis, local radiotherapy improved RFS among patients with multiple recurrence risk factors relative to excision (not reached vs. 19.0 months, p=0.004). Patients with BRCA1-associated protein-1 (BAP1)‒negative primary tumors showed a longer RFS duration after primary treatments, while those with BAP1-negative metastatic tissues had a shorter OS2 compared to those with BAP1-positive tumors, both not statistically insignificance (RFS: not reached vs. 82.0 months, p=0.258; OS2: 15.7 vs. 24.4 months, p=0.216). Male sex (hazard ratio [HR], 3.79; p=0.012), a short RFS (HR, 4.89; p=0.014), and a largest metastatic tumor linear diameter ≥ 45 mm (HR, 5.48; p=0.017) were found to correlate with worse post-recurrence survival. CONCLUSION: Risk factors could be used to classify uveal melanoma cases and subsequently direct individual treatment strategies. Furthermore, metastasectomy appears to contribute to improved survival outcomes.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)
Yonsei Authors
금기창(Keum, Ki Chang) ORCID logo https://orcid.org/0000-0003-4123-7998
김지형(Kim, Jee Hung) ORCID logo https://orcid.org/0000-0002-9044-8540
신상준(Shin, Sang Joon)
윤진숙(Yoon, Jin Sook) ORCID logo https://orcid.org/0000-0002-8751-9467
이성철(Lee, Sung Chul) ORCID logo https://orcid.org/0000-0001-9438-2385
정민규(Jung, Min Kyu) ORCID logo https://orcid.org/0000-0001-8281-3387
최은아(Choe, Eun Ah)
허수진(Heo, Su Jin) ORCID logo https://orcid.org/0000-0002-0615-5869
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