Cited 10 times in
Prognoses and Clinical Outcomes of Primary and Recurrent Uveal Melanoma.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 금기창 | - |
dc.contributor.author | 김지형 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 윤진숙 | - |
dc.contributor.author | 이성철 | - |
dc.contributor.author | 정민규 | - |
dc.contributor.author | 최은아 | - |
dc.contributor.author | 허수진 | - |
dc.date.accessioned | 2018-11-16T16:45:27Z | - |
dc.date.available | 2018-11-16T16:45:27Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165292 | - |
dc.description.abstract | PURPOSE: Uveal melanoma has a very poor prognosis despite successful local primary tumor treatment. In this study, we investigated prognostic factors that more accurately reflected the likelihood ofrecurrence and survival and delineated a prognostic model that could effectively identify different risk groups based on initial clinical parameters. Materials and Methods: Prognostic factors associated with distant recurrence, recurrence-free survival (RFS), progression-free survival, and overall survival from distant recurrence to death (OS2) were analyzed in 226 patients with stage I-III uveal melanoma who underwent primary local therapy. RESULTS: Forty-nine patients (21.7%) had distant recurrences, which occurred most frequently in the liver (87.7%). In a multivariate analysis, local radiotherapy improved RFS among patients with multiple recurrence risk factors relative to excision (not reached vs. 19.0 months, p=0.004). Patients with BRCA1-associated protein-1 (BAP1)‒negative primary tumors showed a longer RFS duration after primary treatments, while those with BAP1-negative metastatic tissues had a shorter OS2 compared to those with BAP1-positive tumors, both not statistically insignificance (RFS: not reached vs. 82.0 months, p=0.258; OS2: 15.7 vs. 24.4 months, p=0.216). Male sex (hazard ratio [HR], 3.79; p=0.012), a short RFS (HR, 4.89; p=0.014), and a largest metastatic tumor linear diameter ≥ 45 mm (HR, 5.48; p=0.017) were found to correlate with worse post-recurrence survival. CONCLUSION: Risk factors could be used to classify uveal melanoma cases and subsequently direct individual treatment strategies. Furthermore, metastasectomy appears to contribute to improved survival outcomes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Prognoses and Clinical Outcomes of Primary and Recurrent Uveal Melanoma. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Jee Hung Kim | - |
dc.contributor.googleauthor | Su-Jin Shin | - |
dc.contributor.googleauthor | Soo Jin Heo | - |
dc.contributor.googleauthor | Eun-Ah Choe | - |
dc.contributor.googleauthor | Chang Gon Kim | - |
dc.contributor.googleauthor | Minkyu Jung | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Jin Sook Yoon | - |
dc.contributor.googleauthor | Sung Chul Lee | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.identifier.doi | 10.4143/crt.2017.534 | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00999 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02611 | - |
dc.contributor.localId | A02873 | - |
dc.contributor.localId | A03606 | - |
dc.contributor.localId | A05429 | - |
dc.contributor.localId | A04355 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 29281872 | - |
dc.subject.keyword | BAP1 | - |
dc.subject.keyword | Melanoma | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Recurrence | - |
dc.subject.keyword | Survival | - |
dc.subject.keyword | Uveal neoplasm | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Kim, Jee Hung | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Yoon, Jin Sook | - |
dc.contributor.alternativeName | Lee, Sung Chul | - |
dc.contributor.alternativeName | Jung, Min Kyu | - |
dc.contributor.alternativeName | Choe, Eun Ah | - |
dc.contributor.alternativeName | Heo, Su Jin | - |
dc.contributor.affiliatedAuthor | 금기창 | - |
dc.contributor.affiliatedAuthor | 김지형 | - |
dc.contributor.affiliatedAuthor | 신상준 | - |
dc.contributor.affiliatedAuthor | 윤진숙 | - |
dc.contributor.affiliatedAuthor | 이성철 | - |
dc.contributor.affiliatedAuthor | 정민규 | - |
dc.contributor.affiliatedAuthor | 최은아 | - |
dc.contributor.affiliatedAuthor | 허수진 | - |
dc.citation.volume | 50 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1238 | - |
dc.citation.endPage | 1251 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.50(4) : 1238-1251, 2018 | - |
dc.identifier.rimsid | 58705 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.