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Total IgG의 신속한 반정량 검사키트 ImmuneCheck™ IgG의 임상적 유용성

Other Titles
 Clinical Usefulness of ImmuneCheck™ IgG for Rapid Semiquantitation of Total IgG 
Authors
 Jinyoung Choi  ;  Sang Chul Lee  ;  Kyung Hee Park  ;  Heylyeong Yoon  ;  Hyon Suk Kim  ;  Jung-Won Park 
Citation
 Laboratory Medicine Online, Vol.8(4) : 140-147, 2018 
Journal Title
 Laboratory Medicine Online 
Issue Date
2018
Keywords
Total IgG POCT ; Rapid semiquantitation ; Total IgG assay
Abstract
Background: Conventional IgG assays require costly equipment and skilled experts. Semiquantitative measurement of total IgG using point-of-care testing devices may be the solution for these limitations. This study evaluated the reproducibility of the ImmuneCheck™ IgG assay (ProteomeTech Inc., Korea) and the correlation of its results with conventional laboratory IgG results in the serum and whole blood. Methods: Both the serum and whole blood samples from 120 patients were used. To evaluate the intra-test reproducibility and inter-test correlation, intraclass correlation coefficient (ICC) analysis was used. Results: The concentration of serum total IgG measured by cobas® 6000 (Roche Diagnostics, Switzland) ranged from 690.4 to 2,756.4 mg/dL. The intra-test reproducibility of ImmuneCheck™ IgG was high (Serum ICC=0.724, P<0.001; Whole blood ICC=0.843, P<0.001). The inter-test correlation between the ImmuneCheck™ IgG and cobas® 6000 results was very good (Serum ICC=0.805, P<0.001; Whole blood ICC=0.842, P<0.001). Because there were no samples with a total IgG level lower than 600 mg/dL, the pre-existing serum samples were diluted and then the linearity tests were conducted. The intra-test reproducibility for the diluted serum samples was almost perfect (ICC=0.995, P<0.001), and the inter-test correlation between the ImmuneCheck™ IgG and cobas® 6000 results was also strong (ICC=0.992, P<0.001). Conclusions: The ImmuneCheck™ IgG assay is reproducible and highly correlated with the conventional IgG assay for the serum and whole blood. It could be applied for the rapid detection of total IgG
Files in This Item:
T201803766.pdf Download
DOI
10.3343/lmo.2018.8.4.140
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김현숙(Kim, Hyon Suk) ORCID logo https://orcid.org/0000-0001-5662-7740
박경희(Park, Kyung Hee) ORCID logo https://orcid.org/0000-0003-3605-5364
박중원(Park, Jung Won) ORCID logo https://orcid.org/0000-0003-0249-8749
이상철(Lee, Sang Chul)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165282
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