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Total IgG의 신속한 반정량 검사키트 ImmuneCheck™ IgG의 임상적 유용성

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dc.contributor.author김현숙-
dc.contributor.author박경희-
dc.contributor.author박중원-
dc.contributor.author이상철-
dc.date.accessioned2018-11-16T16:44:35Z-
dc.date.available2018-11-16T16:44:35Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165282-
dc.description.abstractBackground: Conventional IgG assays require costly equipment and skilled experts. Semiquantitative measurement of total IgG using point-of-care testing devices may be the solution for these limitations. This study evaluated the reproducibility of the ImmuneCheck™ IgG assay (ProteomeTech Inc., Korea) and the correlation of its results with conventional laboratory IgG results in the serum and whole blood. Methods: Both the serum and whole blood samples from 120 patients were used. To evaluate the intra-test reproducibility and inter-test correlation, intraclass correlation coefficient (ICC) analysis was used. Results: The concentration of serum total IgG measured by cobas® 6000 (Roche Diagnostics, Switzland) ranged from 690.4 to 2,756.4 mg/dL. The intra-test reproducibility of ImmuneCheck™ IgG was high (Serum ICC=0.724, P<0.001; Whole blood ICC=0.843, P<0.001). The inter-test correlation between the ImmuneCheck™ IgG and cobas® 6000 results was very good (Serum ICC=0.805, P<0.001; Whole blood ICC=0.842, P<0.001). Because there were no samples with a total IgG level lower than 600 mg/dL, the pre-existing serum samples were diluted and then the linearity tests were conducted. The intra-test reproducibility for the diluted serum samples was almost perfect (ICC=0.995, P<0.001), and the inter-test correlation between the ImmuneCheck™ IgG and cobas® 6000 results was also strong (ICC=0.992, P<0.001). Conclusions: The ImmuneCheck™ IgG assay is reproducible and highly correlated with the conventional IgG assay for the serum and whole blood. It could be applied for the rapid detection of total IgG-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisherKorean Society for Laboratory Medicine-
dc.relation.isPartOfLaboratory Medicine Online-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleTotal IgG의 신속한 반정량 검사키트 ImmuneCheck™ IgG의 임상적 유용성-
dc.title.alternativeClinical Usefulness of ImmuneCheck™ IgG for Rapid Semiquantitation of Total IgG-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthor최진영-
dc.contributor.googleauthor이상철-
dc.contributor.googleauthor박경희-
dc.contributor.googleauthor윤혜령-
dc.contributor.googleauthor김현숙-
dc.contributor.googleauthor박중원-
dc.identifier.doi10.3343/lmo.2018.8.4.140-
dc.contributor.localIdA01117-
dc.contributor.localIdA01427-
dc.contributor.localIdA01681-
dc.contributor.localIdA02831-
dc.relation.journalcodeJ02151-
dc.identifier.eissn2093-6338-
dc.subject.keywordTotal IgG POCT-
dc.subject.keywordRapid semiquantitation-
dc.subject.keywordTotal IgG assay-
dc.contributor.alternativeNameKim, Hyon Suk-
dc.contributor.alternativeNamePark, Kyung Hee-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.alternativeNameLee, Sang Chul-
dc.contributor.affiliatedAuthor김현숙-
dc.contributor.affiliatedAuthor박경희-
dc.contributor.affiliatedAuthor박중원-
dc.contributor.affiliatedAuthor이상철-
dc.citation.volume8-
dc.citation.number4-
dc.citation.startPage140-
dc.citation.endPage147-
dc.identifier.bibliographicCitationLaboratory Medicine Online, Vol.8(4) : 140-147, 2018-
dc.identifier.rimsid58696-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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