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T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells.

Authors
 Hye-Ran Kim  ;  YeVin Mun  ;  Kyung-Sik Lee  ;  Yoo-Jin Park  ;  Jeong-Su Park  ;  Jin-Hwa Park  ;  Bu-Nam Jeon  ;  Chang-Hyun Kim  ;  Youngsoo Jun  ;  Young-Min Hyun  ;  Minsoo Kim  ;  Sang-Myeong Lee  ;  Chul-Seung Park  ;  Sin-Hyeog Im  ;  Chang-Duk Jun 
Citation
 Nature Communications, Vol.9 : 3630, 2018 
Journal Title
 Nature Communications 
Issue Date
2018
Abstract
Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto the surface of cognate antigen-bearing APCs. Microvilli carry T cell receptors (TCR) at all stages of T cell activation and are released as large TCR-enriched, T cell microvilli particles (TMP) in a process of trogocytosis. These microvilli exclusively contain protein arrestin-domain-containing protein 1, which is directly involved in membrane budding and, in combination with vacuolar protein-sorting-associated protein 4, transforms large TMPs into smaller, exosome-sized TMPs. Notably, TMPs from CD4+ T cells are enriched with LFA-2/CD2 and various cytokines involved in activating dendritic cells. Collectively, these results demonstrate that T cell microvilli constitute "immunological synaptosomes" that carry T cell messages to APCs.
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DOI
10.1038/s41467-018-06090-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165276
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