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Risk factors for mortality in patients with Pseudomonas aeruginosa pneumonia: Clinical impact of mucA gene mutation.

Authors
 In Young Jung  ;  Su Jin Jeong  ;  Kang-Mu Lee  ;  Jin Young Ahn  ;  Nam Su Ku  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  Dongeun Yong  ;  Sang Sun Yoon  ;  Young Goo Song  ;  Seok Hoon Jeong  ;  June Myung Kim  ;  Kyungwon Lee 
Citation
 Respiratory Medicine, Vol.140 : 27-31, 2018 
Journal Title
 Respiratory Medicine 
ISSN
 0954-6111 
Issue Date
2018
Keywords
Chronic obstructive pulmonary disease ; Mortality ; Pseudomonas aeruginosa pneumonia ; mucA gene mutation
Abstract
OBJECTIVES: Pseudomonas aeruginosa frequently colonizes the lungs of chronic obstructive pulmonary disease (COPD) patients. Mucoid conversion is a hallmark of chronic P. aeruginosa infection, which is mediated by mucA gene mutations. The aim of this study is to identify predictive factors for mortality and the influence of mucA gene mutation in COPD patients with P. aeruginosa pneumonia. METHODS: This study assessed 75 COPD patients with P. aeruginosa pneumonia at two university hospitals. The clinical and laboratory data were collected, and the P. aeruginosa isolates analyzed for the presence of mucA gene mutations. RESULTS: MucA gene mutation of P. aeruginosa was an independent predictor of mortality (odds ratio [OR] 10.43, 95% confidence interval [CI]: 1.53-70.90, p = 0.017). In addition, the APACHE II score and C-reactive protein/Albumin (CA) ratio were independent predictive factors for mortality (OR 1.25, 95% CI: 1.07-1.46, p = 0.004; and OR 1.06, 95% CI: 1.02-1.10, p = 0.003, respectively). The optimal cutoff value of CA ratio for the greatest sensitivity and specificity was calculated as 31.27 (sensitivity, 85.7%; specificity, 80.3%). CONCLUSIONS: CA ratio and mucA gene mutation of P. aeruginosa could be used as predictors to identify poor prognosis in COPD patients with P. aeruginosa pneumonia.
Full Text
https://www.sciencedirect.com/science/article/pii/S0954611118301793
DOI
10.1016/j.rmed.2018.05.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
구남수(Ku, Nam Su) ORCID logo https://orcid.org/0000-0002-9717-4327
김준명(Kim, June Myung)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
안진영(Ahn, Jin Young) ORCID logo https://orcid.org/0000-0002-3740-2826
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
윤상선(Yoon, Sang Sun) ORCID logo https://orcid.org/0000-0003-2979-365X
이강무(Lee, Kang Mu) ORCID logo https://orcid.org/0000-0001-7414-5921
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
정석훈(Jeong, Seok Hoon) ORCID logo https://orcid.org/0000-0001-9290-897X
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
정인영(Jung, In Young)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165271
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