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Scaffold Free Bone Regeneration Using Platelet-Rich Fibrin in Calvarial Defect Model

Authors
 Yeo Reum Jeon  ;  Mi Jung Kim  ;  Yong Oock Kim  ;  Tai Suk Roh  ;  Won Jai Lee  ;  Eun Hye Kang  ;  In Sik Yun 
Citation
 Journal of Craniofacial Surgery, Vol.29(1) : 251-254, 2018 
Journal Title
 Journal of Craniofacial Surgery 
ISSN
 1049-2275 
Issue Date
2018
MeSH
Animals ; Bone Regeneration* ; Fibrin ; Gelatin Sponge, Absorbable ; Imaging, Three-Dimensional ; Male ; Osteogenesis ; Platelet-Rich Fibrin* ; Platelet-Rich Plasma* ; Rabbits ; Skull/cytology ; Skull/diagnostic imaging ; Skull/injuries ; Skull/physiology* ; Tomography, X-Ray Computed
Keywords
Adjuvant ; calvarial bone regeneration ; osteogenic potential ; platelet-rich fibrin ; platelet-rich plasma
Abstract
Bone regeneration is a complex process influenced by various physiological factors. Platelet-rich plasma (PRP) contains many growth factors and has shown osteogenic effects. The PRP is usually activated before use. However, the authors showed that nonactivated PRP (nPRP) and activated PRP have comparable osteogenic effects in the previous study. Generally, a scaffold has been needed for the application of PRP in the cranial defect model. In this study, the authors aimed to compare the performance of scaffold free platelet-rich fibrin (PRF) to nPRP as an adjuvant for bone regeneration.Twenty-four New Zealand White rabbits were randomly allocated into 3 groups: control, nPRP, and PRF. A 15 × 15 mm defect was created on each rabbit's cranium. Acellular collagen sponges (Gelfoam) were placed on the defects of the control group, Gelfoam with nPRP was used for the nPRP group, and PRF membrane was directly applied for the PRF group. nPRP and PRF were obtained from each subject's peripheral blood. Sixteen weeks later, the volume of regenerated bone was measured using 3-dimensional computed tomography. The surface area was measured via autopsy, and the samples were then obtained for histological analysis.Bone regeneration in the experimental groups was significantly greater than that in the control group. There were no significant differences in the area of regeneration or histological characteristics between the nPRP and PRF groups.In the calvarial defect of the rabbits, the use of PRF and scaffolded PRP showed comparable bone regeneration effects, which suggested that PRF might be a therapeutic alternative for bone grafts.
Full Text
https://insights.ovid.com/pubmed?pmid=29215443
DOI
10.1097/SCS.0000000000004210
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
김미정(Kim, Mi Jung)
김용욱(Kim, Yong Oock) ORCID logo https://orcid.org/0000-0002-3756-4809
노태석(Roh, Tai Suk) ORCID logo https://orcid.org/0000-0001-8681-159X
윤인식(Yun, In Sik) ORCID logo https://orcid.org/0000-0003-1103-7047
이원재(Lee, Won Jai) ORCID logo https://orcid.org/0000-0003-3056-0503
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165260
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