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Association between retinal vein occlusion and risk of heart failure: A 12-year nationwide cohort study

 Tyler Hyungtaek Rim  ;  Jaewon Oh  ;  Seok-Min Kang  ;  Sung Soo Kim 
 International Journal of Cardiology, Vol.217 : 122-127, 2016 
Journal Title
 International Journal of Cardiology 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Female ; Heart Failure/epidemiology* ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Propensity Score ; Republic of Korea/epidemiology ; Retinal Vein Occlusion/epidemiology* ; Retrospective Studies ; Risk Factors
Heart failure ; Retinal vein occlusion ; Risk factors
BACKGROUNDS: Retinal vein occlusion (RVO) is one of the major causes of visual impairment in elderly people. Risk factors for RVO are also common risk factors for cardiovascular disease, including heart failure (HF). However, the association between RVO and HF has not been evaluated. METHODS AND RESULTS: A retrospective propensity-score matched cohort study was conducted using national representative 1 million samples from the Korea National Health Insurance Service. The RVO group included patients with a first diagnosis of either central or branch RVO (n=1754) and the comparison group included randomly selected patients (n=8749) who were matched to sociodemographic factors and the year of RVO diagnosis. In the longitudinal cohort, HF developed in 11.6% and 8.0% of patients in the RVO and comparison groups, respectively, (p<0.001) during the 11-year follow-up period (median, 7.6years). RVO was significantly associated with an increased risk of HF after multivariable adjustment (HR=1.36; 95% CI, 1.16-1.60). In terms of HF subtypes, RVO was associated with the risk of ischemic HF but not with the risk of non-ischemic HF. The effect size (~HR) for HF by RVO was larger in patients without each comorbidity than in patients with each comorbidity. CONCLUSIONS: Our observational study on nationwide data suggests that RVO is associated with an increased risk of the incidence of HF, especially ischemic HF. An optimal surveillance strategy and referring from ophthalmologists to cardiologists should be considered in the presence of one or more additional HF risk factors in patients with RVO.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Rim, Tyler Hyungtaek(임형택)
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