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Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches

Authors
 Kook Hwan Kim  ;  Myung-Shik Lee 
Citation
 FRONTIERS IN ENDOCRINOLOGY, Vol.9 : 485, 2018 
Journal Title
 FRONTIERS IN ENDOCRINOLOGY 
Issue Date
2018
Keywords
NAFLD ; NASH ; fibrosis ; inflammation ; multiple-parallel hit ; steatosis
Abstract
Non-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for type 2 diabetes, cardiovascular disease, and chronic kidney disease. Nonalcoholic steatohepatitis (NASH), an advanced form of NAFLD, is a predisposing factor for development of cirrhosis and hepatocellular carcinoma. The increasing prevalence of NASH emphasizes the need for novel therapeutic approaches. Although therapeutic drugs against NASH are not yet available, fundamental insights into the pathogenesis of NASH have been made during the past few decades. Multiple therapeutic strategies have been developed and are currently being explored in clinical trials or preclinical testing. The pathogenesis of NASH involves multiple intracellular/extracellular events in various cell types in the liver or crosstalk events between the liver and other organs. Here, we review current findings and knowledge regarding the pathogenesis of NASH, focusing on the most recent advances. We also highlight hormone-based therapeutic approaches for treatment of NASH.
Files in This Item:
T201803748.pdf Download
DOI
10.3389/fendo.2018.00485
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Kook Hwan(김국환)
Lee, Myung Shik(이명식) ORCID logo https://orcid.org/0000-0003-3292-1720
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165068
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