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Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches

DC FieldValueLanguage
dc.contributor.author김국환-
dc.contributor.author이명식-
dc.date.accessioned2018-11-06T16:40:28Z-
dc.date.available2018-11-06T16:40:28Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165068-
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for type 2 diabetes, cardiovascular disease, and chronic kidney disease. Nonalcoholic steatohepatitis (NASH), an advanced form of NAFLD, is a predisposing factor for development of cirrhosis and hepatocellular carcinoma. The increasing prevalence of NASH emphasizes the need for novel therapeutic approaches. Although therapeutic drugs against NASH are not yet available, fundamental insights into the pathogenesis of NASH have been made during the past few decades. Multiple therapeutic strategies have been developed and are currently being explored in clinical trials or preclinical testing. The pathogenesis of NASH involves multiple intracellular/extracellular events in various cell types in the liver or crosstalk events between the liver and other organs. Here, we review current findings and knowledge regarding the pathogenesis of NASH, focusing on the most recent advances. We also highlight hormone-based therapeutic approaches for treatment of NASH.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherFrontiers Research-
dc.relation.isPartOfFrontiers in Endocrinology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorKook Hwan Kim-
dc.contributor.googleauthorMyung-Shik Lee-
dc.identifier.doi10.3389/fendo.2018.00485-
dc.contributor.localIdA04716-
dc.contributor.localIdA04716-
dc.contributor.localIdA02752-
dc.relation.journalcodeJ03412-
dc.identifier.eissn1664-2392-
dc.identifier.pmid30197624-
dc.subject.keywordNAFLD-
dc.subject.keywordNASH-
dc.subject.keywordfibrosis-
dc.subject.keywordinflammation-
dc.subject.keywordmultiple-parallel hit-
dc.subject.keywordsteatosis-
dc.contributor.alternativeNameKim, Kook Hwan-
dc.contributor.alternativeNameLee, Myung Shik-
dc.contributor.affiliatedAuthor김국환-
dc.contributor.affiliatedAuthor이명식-
dc.citation.volume9-
dc.citation.startPage485-
dc.identifier.bibliographicCitationFrontiers in Endocrinology, Vol.9 : 485, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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