Cited 66 times in
Marked Loss of Muscle, Visceral Fat, or Subcutaneous Fat After Gastrectomy Predicts Poor Survival in Advanced Gastric Cancer: Single-Center Study from the CLASSIC Trial
DC Field | Value | Language |
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dc.contributor.author | 김지형 | - |
dc.contributor.author | 김형일 | - |
dc.contributor.author | 김효송 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 박형순 | - |
dc.contributor.author | 백송이 | - |
dc.contributor.author | 범승훈 | - |
dc.contributor.author | 손태일 | - |
dc.contributor.author | 임준석 | - |
dc.contributor.author | 정민규 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 최은아 | - |
dc.contributor.author | 허수진 | - |
dc.contributor.author | 형우진 | - |
dc.contributor.author | 이시원 | - |
dc.date.accessioned | 2018-10-22T13:20:35Z | - |
dc.date.available | 2018-10-22T13:20:35Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163778 | - |
dc.description.abstract | BACKGROUND: There is increasing interest in the influence of body composition on oncological outcomes. We evaluated the role of skeletal muscle and fat among patients with gastric cancer (GC) who underwent gastrectomy with or without adjuvant chemotherapy, as well as those changes' associations with survival outcomes. METHODS: The present study evaluated 136 patients with GC who were enrolled in the CLASSIC Trial at Yonsei Cancer Center. Baseline body compositions including skeletal muscle area, Hounsfield units (HU), visceral fat area, and subcutaneous fat area were measured by preoperative computed tomography (CT). CT before and after the gastrectomy were used to determine the 6-month relative changes in body composition parameters. Continuous variables were dichotomized according to the best cutoff values by Contal and O'Quigley method. RESULTS: Seventy-three patients (53.7%) underwent surgery alone, and 63 patients (46.3%) underwent surgery followed by adjuvant chemotherapy. The baseline body composition parameters were not associated with disease-free survival (DFS) or overall survival (OS). Except for the HU, the marked loss of muscle, visceral fat, or subcutaneous fat significantly predicted shorter DFS and OS. Patients with a marked loss in at least one significant body composition parameter had significantly shorter DFS (hazard ratio 2.9, 95% confidence interval 1.7-4.8, P < 0.001) and OS (hazard ratio 2.9, 95% confidence interval 1.7-5.0, P < 0.001). CONCLUSIONS: Marked loss in body composition parameters significantly predicted shorter DFS and OS among patients with GC who underwent gastrectomy. Postoperative nutrition and active healthcare interventions could improve the prognosis of these GC patients | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Marked Loss of Muscle, Visceral Fat, or Subcutaneous Fat After Gastrectomy Predicts Poor Survival in Advanced Gastric Cancer: Single-Center Study from the CLASSIC Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Hyung Soon Park | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.contributor.googleauthor | Seung Hoon Beom | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Jee Hung Kim | - |
dc.contributor.googleauthor | You Jin Chun | - |
dc.contributor.googleauthor | Si Won Lee | - |
dc.contributor.googleauthor | Eun-Ah Choe | - |
dc.contributor.googleauthor | Su Jin Heo | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Woo Jin Hyung | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.contributor.googleauthor | Hyoung-Il Kim | - |
dc.contributor.googleauthor | Taeil Son | - |
dc.contributor.googleauthor | Joon Seok Lim | - |
dc.contributor.googleauthor | Song-Ee Baek | - |
dc.contributor.googleauthor | Minkyu Jung | - |
dc.identifier.doi | 10.1245/s10434-018-6624-1 | - |
dc.contributor.localId | A00999 | - |
dc.contributor.localId | A01154 | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A04576 | - |
dc.contributor.localId | A01822 | - |
dc.contributor.localId | A04581 | - |
dc.contributor.localId | A01998 | - |
dc.contributor.localId | A03408 | - |
dc.contributor.localId | A03606 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A05429 | - |
dc.contributor.localId | A04355 | - |
dc.contributor.localId | A04382 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 30051367 | - |
dc.identifier.url | https://link.springer.com/article/10.1245%2Fs10434-018-6624-1 | - |
dc.contributor.alternativeName | Kim, Jee Hung | - |
dc.contributor.alternativeName | Kim, Hyoung Il | - |
dc.contributor.alternativeName | Kim, Hyo Song | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Park, Hyung Soon | - |
dc.contributor.alternativeName | Baek, Song Ee | - |
dc.contributor.alternativeName | Beum, Seung Hoon | - |
dc.contributor.alternativeName | Son, Tae Il | - |
dc.contributor.alternativeName | Lim, Joon Seok | - |
dc.contributor.alternativeName | Jung, Min Kyu | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Choe, Eun Ah | - |
dc.contributor.alternativeName | Heo, Su Jin | - |
dc.contributor.alternativeName | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Kim, Jee Hung | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Il | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Song | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | Park, Hyung Soon | - |
dc.contributor.affiliatedAuthor | Baek, Song Ee | - |
dc.contributor.affiliatedAuthor | Beum, Seung Hoon | - |
dc.contributor.affiliatedAuthor | Son, Tae Il | - |
dc.contributor.affiliatedAuthor | Lim, Joon Seok | - |
dc.contributor.affiliatedAuthor | Jung, Min Kyu | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Choe, Eun Ah | - |
dc.contributor.affiliatedAuthor | Heo, Su Jin | - |
dc.contributor.affiliatedAuthor | Hyung, Woo Jin | - |
dc.citation.volume | 25 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3222 | - |
dc.citation.endPage | 3230 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.25(11) : 3222-3230, 2018 | - |
dc.identifier.rimsid | 59073 | - |
dc.type.rims | ART | - |
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