0 39

Cited 0 times in

Metabolic syndrome and its components as risk factors for prolonged corrected QT interval in apparently healthy Korean men and women

Authors
 Byoungjin Park  ;  Yong-Jae Lee 
Citation
 Journal of Clinical Lipidology, Vol.12(5) : 1298-1304, 2018 
Journal Title
 Journal of Clinical Lipidology 
ISSN
 1933-2874 
Issue Date
2018
Keywords
Arrhythmia ; Insulin resistance ; Metabolic syndrome ; QTc interval
Abstract
BACKGROUND: Metabolic syndrome (MetS) is clinically important because of its association with increased risk of sudden cardiac death, as well as cardiovascular disease-related mortality. Data between MetS and prolonged corrected QT (QTc) intervals, a useful predictor of sudden cardiac death, are limited in apparently healthy adults. OBJECTIVE: This study determined the association between MetS and QTc interval in apparently healthy Korean men and women. METHODS: We examined the association between MetS and QTc interval in 2157 Korean adults (1317 men and 840 women) in a health examination program but excluded participants with a history of ischemic heart disease, stroke, cardiac arrhythmia, cancer, thyroid, respiratory, renal, hepatobiliary, or rheumatologic disease. The QTc interval was calculated using Bazett's formula (QTc = QT/√RR). Multivariate-adjusted mean QTc values by the number of MetS components were calculated after sex stratification and compared using analysis of covariance test. RESULTS: The overall prevalence of MetS was 30.5% in men and 19.8% in women. The QTc interval positively correlated with age, body mass index, blood pressure, fasting plasma glucose, triglycerides, and potassium level in both men and women and negatively correlated with calcium and potassium levels and smoking status in men. The multivariate-adjusted mean QTc value increased proportionally with increasing number of MetS components (P values < 0.001 for both men and women). CONCLUSION: We confirmed the arrhythmogenic potential of MetS in apparently healthy Korean men and women. These findings suggest that careful monitoring of electrocardiography is necessary to evaluate possible arrhythmic risk in individuals with MetS.
Full Text
https://www.sciencedirect.com/science/article/pii/S1933287418303039
DOI
10.1016/j.jacl.2018.07.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
박병진(Park, Byoung Jin) ORCID logo https://orcid.org/0000-0003-1733-5301
이용제(Lee, Yong Jae) ORCID logo https://orcid.org/0000-0002-6697-476X
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163743
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse