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Clinical outcomes of and management strategy for perforations associated with endoscopic submucosal dissection of an upper gastrointestinal epithelial neoplasm

Authors
 Hyun Ju Kim  ;  Hyunsoo Chung  ;  Da Hyun Jung  ;  Jun Chul Park  ;  Sung Kwan Shin  ;  Sang Kil Lee  ;  Yong Chan Lee 
Citation
 Surgical Endoscopy , Vol.30(11) : 5059-5067, 2016 
Journal Title
 Surgical Endoscopy  
ISSN
 0930-2794 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Endoscopic Mucosal Resection/adverse effects* ; Endoscopic Mucosal Resection/methods ; Endoscopy ; Female ; Humans ; Intestinal Perforation/epidemiology ; Intestinal Perforation/prevention & control ; Male ; Middle Aged ; Neoplasms, Glandular and Epithelial/surgery* ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Republic of Korea ; Retrospective Studies ; Risk Factors ; Stomach Neoplasms/surgery* ; Treatment Outcome
Keywords
Endoscopic submucosal dissection ; Outcomes ; Perforation
Abstract
INTRODUCTION: Perforation is one of the major complications of endoscopic submucosal dissection (ESD). In the present study, we investigated the clinical outcomes of and management strategies for ESD-related perforations. METHODS: Between February 2010 and April 2014, a total of 3821 patients who underwent ESD for an upper gastrointestinal epithelial neoplasm were analyzed using the Yonsei University Severance Hospital database. Clinical outcomes of and management strategies for perforations in 90 patients (2.4 %) were analyzed. The risk factors for the development of perforation were also investigated. RESULTS: The mean age of our subjects was 64.7 ± 12.2 years (male to female ratio, 3.2:1), and the mean size of the resected specimens was 39.4 ± 12.5 mm. Endoscopically visible perforations (visible perforation group) were noted in 74 of the 90 patients (82.2 %), and clinically suspected perforations (suspected perforation group) were noted in 16 patients (17.8 %). Immediate closure with endoclips was attempted in cases with a visible perforation and was successful in 72 (97.3 %) cases. Two patients in whom endoscopic closure failed underwent surgery. Conservative care, including fasting and intravenous antibiotic administration, was attempted in the suspected perforation group, and all the patients were treated successfully without surgery. The mean durations of fasting, antibiotic treatment, and hospital stay were 3.8 ± 3.1, 6.8 ± 4.2, and 8.7 ± 5.3 days, respectively. Subgroup analysis of perforation type (visible perforation vs. suspected perforation) revealed no significant difference in the clinical course. Tumor location at the upper or middle third of the stomach was significantly associated with perforation. CONCLUSION: Most of the ESD-related perforations in upper gastrointestinal epithelial neoplasm could be managed successfully in a non-surgical manner under strict monitoring
Full Text
https://link.springer.com/article/10.1007%2Fs00464-016-4854-5
DOI
10.1007/s00464-016-4854-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Jung, Da Hyun(정다현)
Chung, Hyun Soo(정현수)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163565
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