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Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors

Authors
 Jeong-Kee Yoon  ;  Mi-Lan Kang  ;  Joo Hyun Park  ;  Kyoung-Mi Lee  ;  Young Min Shin  ;  Jin Woo Lee  ;  Hyun Ok Kim  ;  Hak-Joon Sung 
Citation
 STEM CELLS INTERNATIONAL, Vol.2018 : 8642989, 2018 
Journal Title
 STEM CELLS INTERNATIONAL 
ISSN
 1687-966X 
Issue Date
2018
Abstract
Stem cells have recently emerged as an important candidate for cell therapy. However, some major limitations still exist such as a small quantity of cell supply, senescence, and insufficient differentiation efficiency. Therefore, there is an unmet need to control stem cell behavior for better clinical performance. Since native microenvironment factors including stem cell niche, genetic factors, and growth factors direct stem cell fate cooperatively, user-specified in vitro settings are required to understand the regulatory roles and effects of each factor, thereby applying the factors for improved cell therapy. Among others, various types of biomaterials and transfection method have been employed as key tools for development of the in vitro settings. This review focuses on the current strategies to improve stemness maintenance, direct differentiation, and reprogramming using biomaterials and genetic factors without any aids from additional biochemicals and growth factors.
Files in This Item:
T201802958.pdf Download
DOI
10.1155/2018/8642989
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Park, Joo Hyun(박주현)
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
Yoon, Jeong-Kee(윤정기) ORCID logo https://orcid.org/0000-0003-0111-9911
Lee, Kyoung Mi(이경미) ORCID logo https://orcid.org/0000-0002-9038-8162
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163512
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