여성 섬유근육통 환자에서 adenosine triphosphate 정맥주사요법이 통증과 피로 개선에 미치는 효과

Abstract

Background: Fibromyalgia is characterized by chronic, widespread, musculoskeletal pain accompanied by fatigue, psychiatric symptoms and multiple somatic symptoms. Treatments for fibromyalgia include various pharmacological and non-pharmacologic therapies to minimize symptoms and improving general health. This study aimed to investigate the effect of intravenous adenosine triphosphate (ATP) injection on pain and fatigue in female patients with fibromyalgia. Methods: This study included 24 females who visited the department of family medicine at Gangnam Severance Hospital in Seoul, Korea from June 1, 2017 to July 30, 2017. The participants received ATP injection twice a week apart and they conducted questionnaire survey concerning the severity of pain and fatigue scores such as numeric pain intensity scale (NPS), fibromyalgia impact questionnaire (FIQ), widespread pain index (WPI), symptom severity scale (SS), fatigue severity score (FSS) at the initial (0 week), 1st (1 week), and final (2 weeks) visits. The changes of five symptom scores were compared with repeated measures analysis of variance test. Results: The average age of patients was 49.29±8.52 years. Compared with the symptom scores before ATP injection, most of the pain and fatigue scores except WPI were significantly decreased after ATP injection (All P-values<0.05). In particular, FIQ, which is a comprehensive questionnaire to assess pain, sleep disturbance, mood and quality of life of fibromyalgia, was remarkably decreased from 63.08±15.03 to 47.92±17.84 (P=0.004). Conclusion: Our results suggest that ATP injection may be helpful to improve the severity of pain and fatigue scores pain in female patients with fibromyalgia.