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Myocardial Extracellular Volume Fraction and Change in Hematocrit Level: MR Evaluation by Using T1 Mapping in an Experimental Model of Anemia

Authors
 Pan Ki Kim  ;  Yoo Jin Hong  ;  Hajime Sakuma  ;  Ashish Chawla  ;  Jeffrey Kihyun Park  ;  Chul Hwan Park  ;  Donghyun Hong  ;  Kyunghwa Han  ;  Ji Yeon Lee  ;  Jin Hur  ;  Hye-Jeong Lee  ;  Young Jin Kim  ;  Young Joo Suh  ;  Byoung Wook Choi 
Citation
 Radiology, Vol.288(1) : 93-98, 2018 
Journal Title
 Radiology 
ISSN
 0033-8419 
Issue Date
2018
MeSH
Anemia/diagnostic imaging ; Anemia/pathology* ; Animals ; Contrast Media ; Disease Models, Animal ; Heart/diagnostic imaging* ; Hematocrit/statistics & numerical data ; Image Enhancement/methods ; Magnetic Resonance Imaging/methods* ; Male ; Myocardium/pathology* ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results
Abstract
Purpose To evaluate the effect of changes in hematocrit level on myocardial extracellular volume (ECV) fraction, as quantified with cardiac magnetic resonance (MR) imaging in an animal model. Materials and Methods Thirteen adult male Sprague-Dawley rats underwent cardiac MR imaging before and after induction of anemia. MR imaging procedures, including unenhanced and contrast material-enhanced T1 mapping, were performed by using a saturation recovery Look-Locker sequence with a 9.4-T unit. An optimized T1 mapping sequence was established in the phantom study. Systolic function of the left ventricle (LV) was calculated from the cine images. Native and postcontrast T1 values of the LV myocardium at the midcavity level and LV blood pool, partition coefficients, and ECV were calculated. Histopathologic examination of the heart was performed after sacrifice. Intergroup comparison of variables was performed with the paired t test. Results The postanemia models exhibited lower hematocrit levels, postcontrast T1 values of the LV pool, and partition coefficients (mean, 45.7% ± 5.2 [standard deviation]; 563.8 msec ± 155.7; and 29.2 ± 3.5, respectively) than did the preanemia models (mean, 59.0% ± 4.1; 690.2 msec ± 109.7; and 38.2 ± 4.4, respectively) (P < .05 for all comparisons). There were no differences between the pre- and postanemia groups in terms of LV ejection fraction (mean, 72.7% ± 2.1 vs 73.2% ± 4.7; P = .78) and ECV (mean, 15.5% ± 2.0 vs 16.0% ± 1.9; P = .24). Conclusion Myocardial ECV measured with contrast-enhanced T1 mapping cardiac MR imaging did not significantly change despite changes in hematocrit level in anemic rat models. Extrapolation of this finding from animal models to human subjects suggests that ECV measured with MR imaging could be a robust parameter in anemic patients.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163472
DOI
10.1148/radiol.2018171342
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김영진(Kim, Young Jin) ORCID logo https://orcid.org/0000-0002-6235-6550
박철환(Park, Chul Hwan) ORCID logo https://orcid.org/0000-0002-0004-9475
서영주(Suh, Young Joo) ORCID logo https://orcid.org/0000-0002-2078-5832
이혜정(Lee, Hye Jeong) ORCID logo https://orcid.org/0000-0003-4349-9174
최병욱(Choi, Byoung Wook) ORCID logo https://orcid.org/0000-0002-8873-5444
한경화(Han, Kyung Hwa)
허진(Hur, Jin)
홍유진(Hong, Yoo Jin) ORCID logo https://orcid.org/0000-0002-7276-0944
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