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Magnetic resonance enterography predicts the prognosis of Crohn’s disease

Authors
 Ji Hoon Lee  ;  Yong Eun Park  ;  Nieun Seo  ;  Hyun Jung Lee  ;  Soo Jung Park  ;  Tae Il Kim  ;  Won Ho Kim  ;  Joon Seok Lim  ;  Jae Hee Cheon 
Citation
 Intestinal Research, Vol.16(3) : 445-457, 2018 
Journal Title
 Intestinal Research 
ISSN
 1598-9100 
Issue Date
2018
Keywords
Crohn disease ; Magnetic resonance enterography ; Prognosis
Abstract
Background/Aims: Magnetic resonance enterography (MRE) has emerged as an important tool in the diagnosis and follow-up of Crohn's disease (CD). The aim of this study was to evaluate whether MRE findings could predict the prognosis of CD. Methods: In this retrospective study, a total of 173 patients with clinical remission of CD (n=61) or active CD (n=112) were identified. The outcomes of clinical relapse, admission, surgery, and need for other medications according to the MRE findings were evaluated. Results: The presence of active inflammation on MRE was observed in 93 (83%) patients with clinically active CD and in 44 (72.1%) patients with clinical remission of CD, without a statistically significant difference (P=0.091). In multivariate analysis, active inflammation on MRE increased the risk for clinical relapse (hazard ratio [HR], 6.985; 95% confidence interval [CI], 1.024-47.649) in patients with clinical remission of CD. In patients with clinically active CD, active inflammation on MRE increased the risk for CD-related hospitalization (HR, 2.970; 95% CI, 1.006-8.772). Conclusions: The presence of active inflammation on MRE was significantly associated with poor prognosis both in patients with clinical remission of CD and in those with active CD.
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DOI
10.5217/ir.2018.16.3.445
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김원호(Kim, Won Ho)
김태일(Kim, Tae Il) ORCID logo https://orcid.org/0000-0003-4807-890X
박수정(Park, Soo Jung)
박용은(Park, Yong Eun)
서니은(Seo, Nieun) ORCID logo https://orcid.org/0000-0001-8745-6454
이지훈(Lee, Ji Hoon)
이현정(Lee, Hyun Jung)
임준석(Lim, Joon Seok) ORCID logo https://orcid.org/0000-0002-0334-5042
천재희(Cheon, Jae Hee) ORCID logo https://orcid.org/0000-0002-2282-8904
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163315
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