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A Novel Peptide, Nicotinyl⁻Isoleucine⁻Valine⁻Histidine (NA⁻IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells.

Authors
 Dong Hwee Son  ;  Dong Joo Yang  ;  Ji Su Sun  ;  Seul Ki Kim  ;  Namju Kang  ;  Jung Yun Kang  ;  Yun-Hee Choi  ;  Jeong Hun Lee  ;  Sang Hyun Moh  ;  Dong Min Shin  ;  Ki Woo Kim 
Citation
 MARINE DRUGS, Vol.16(8) : 262, 2018 
Journal Title
 MARINE DRUGS 
Issue Date
2018
Keywords
antioxidant ; isoleucine-valine-histidine ; nicotinamide ; nuclear factor (erythroid-derived 2)-like factor ; wound-healing
Abstract
Nicotinamide (NA), a water-soluble vitamin B₃, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl⁻isoleucine⁻valine⁻histidine (NA⁻IVH), by combining NA with jellyfish peptides' IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA⁻IVH. We found that NA⁻IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA⁻IVH protected the cells from hydrogen peroxide (H₂O₂)-induced cell death. Interestingly, NA⁻IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA⁻IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS.
Files in This Item:
T201802563.pdf Download
DOI
10.3390/md16080262
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Woo(김기우) ORCID logo https://orcid.org/0000-0002-7790-1515
Shin, Dong Min(신동민) ORCID logo https://orcid.org/0000-0001-6042-0435
Choi, Yun Hee(최윤희) ORCID logo https://orcid.org/0000-0002-3519-8841
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163215
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