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A Novel Peptide, Nicotinyl⁻Isoleucine⁻Valine⁻Histidine (NA⁻IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells.

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dc.contributor.author신동민-
dc.contributor.author김기우-
dc.contributor.author최윤희-
dc.date.accessioned2018-09-28T08:54:49Z-
dc.date.available2018-09-28T08:54:49Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163215-
dc.description.abstractNicotinamide (NA), a water-soluble vitamin B₃, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl⁻isoleucine⁻valine⁻histidine (NA⁻IVH), by combining NA with jellyfish peptides' IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA⁻IVH. We found that NA⁻IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA⁻IVH protected the cells from hydrogen peroxide (H₂O₂)-induced cell death. Interestingly, NA⁻IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA⁻IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfMARINE DRUGS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA Novel Peptide, Nicotinyl⁻Isoleucine⁻Valine⁻Histidine (NA⁻IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells.-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral Biology-
dc.contributor.googleauthorDong Hwee Son-
dc.contributor.googleauthorDong Joo Yang-
dc.contributor.googleauthorJi Su Sun-
dc.contributor.googleauthorSeul Ki Kim-
dc.contributor.googleauthorNamju Kang-
dc.contributor.googleauthorJung Yun Kang-
dc.contributor.googleauthorYun-Hee Choi-
dc.contributor.googleauthorJeong Hun Lee-
dc.contributor.googleauthorSang Hyun Moh-
dc.contributor.googleauthorDong Min Shin-
dc.contributor.googleauthorKi Woo Kim-
dc.identifier.doi10.3390/md16080262-
dc.contributor.localIdA02091-
dc.relation.journalcodeJ02181-
dc.identifier.eissn1660-3397-
dc.identifier.pmid30071627-
dc.subject.keywordantioxidant-
dc.subject.keywordisoleucine-valine-histidine-
dc.subject.keywordnicotinamide-
dc.subject.keywordnuclear factor (erythroid-derived 2)-like factor-
dc.subject.keywordwound-healing-
dc.contributor.alternativeNameShin, Dong Min-
dc.contributor.affiliatedAuthorShin, Dong Min-
dc.citation.volume16-
dc.citation.number8-
dc.citation.startPage262-
dc.identifier.bibliographicCitationMARINE DRUGS, Vol.16(8) : 262, 2018-
dc.identifier.rimsid58482-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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