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Real-time monitoring of cancer cells in liver mouse bone marrow

Authors
 Sung Hwan Lee  ;  Sang A Park  ;  Yunyun Zou  ;  Sang-Uk Seo  ;  Chang-Duk Jun  ;  Woo Jung Lee  ;  Young-Min Hyun  ;  Nam Hoon Cho 
Citation
 Frontiers in Immunology, Vol.9 : 1681, 2018 
Journal Title
 Frontiers in Immunology 
Issue Date
2018
Keywords
two-photon microscopy ; intravital imaging ; bone marrow microenvironment ; tumor cell dormancy ; cancer cell
Abstract
Disseminated tumor cells in the bone marrow environment are the main cause of systemic metastasis after curative treatment for major solid tumors. However, the detailed biological processes of tumor biology in bone marrow have not been well defined in a real-time manner, because of a lack of a proper in vivo experimental model thereof. In this study, we established intravital imaging models of the bone marrow environment to enable real-time observation of cancer cells in the bone marrow. Using these novel imaging models of intact bone marrow and transplanted bone marrow of mice, respectively, via two-photon microscopy, we could first successfully track and analyze both the distribution and the phenotype of cancer cells in bone marrow of live mouse. Therefore, these novel in vivo imaging models for the bone marrow would provide a valuable tool to identify the biologic processes of cancer cells in a real-time manner in a live animal model.
Files in This Item:
T201802413.pdf Download
DOI
10.3389/fimmu.2018.01681
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
이우정(Lee, Woo Jung) ORCID logo https://orcid.org/0000-0001-9273-261X
조남훈(Cho, Nam Hoon) ORCID logo https://orcid.org/0000-0002-0045-6441
현영민(Hyun, Young-Min) ORCID logo https://orcid.org/0000-0002-0567-2039
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163189
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