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Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fibrosis in children

 Hyun Joo Shin  ;  Haesung Yoon  ;  Myung-Joon Kim  ;  Seok Joo Han  ;  Hong Koh  ;  Seung Kim  ;  Mi-Jung Lee 
 World Journal of Gastroenterology, Vol.24(27) : 3013-3020, 2018 
Journal Title
 World Journal of Gastroenterology 
Issue Date
Diffusion-weighted imaging ; Fatty liver ; Fibrosis ; Intravoxel incoherent motion ; Pediatrics
AIM: To evaluate the correlation between intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters and the degree of hepatic steatosis and fibrosis in children. METHODS: This retrospective study was approved by the institutional review board. The children (≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver (FAT), and fibrotic liver (FIB) groups. The slow diffusion coefficient (D), fast diffusion coefficient (D*), perfusion fraction (f), and apparent diffusion coefficient (ADC) were measured. MR proton density fat fraction (PDFF), MR elastography (MRE), and IVIM values were compared. RESULTS: A total of 123 children (median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D* values were lower in the FIB group compared with those of the normal (P = 0.015) and FAT (P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group (P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value (β = 3.194, P < 0.001), and MRE value was negatively correlated with D* value (β = -7.031, P = 0.032). The D and ADC values were not influenced by PDFF or MRE value. CONCLUSION: In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffness and endovascular blood flow velocity, while diffusion-related parameters were not affected.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
고홍(Koh, Hong) ORCID logo https://orcid.org/0000-0002-3660-7483
김명준(Kim, Myung Joon) ORCID logo https://orcid.org/0000-0002-4608-0275
김승(Kim, Seung) ORCID logo https://orcid.org/0000-0003-4373-9828
신현주(Shin, Hyun Joo) ORCID logo https://orcid.org/0000-0002-7462-2609
윤혜성(Yoon, Haesung) ORCID logo https://orcid.org/0000-0003-0581-8656
이미정(Lee, Mi-Jung) ORCID logo https://orcid.org/0000-0003-3244-9171
한석주(Han, Seok Joo) ORCID logo https://orcid.org/0000-0001-5224-1437
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