50세 이상 한국 여성들에게서 혈청 암배아항원 농도와 대사증후군의 관련성

Abstract

Background: The objective of this study was to investigate the relationship between serum carcinoembryonic antigen (CEA) levels and metabolic syndrome in Korean women aged ≥50 years old. Methods: This cross-sectional study included a total of 3,479 individuals who underwent health check-ups between November 2006 and July 2010 at the Health Promotion Center of Gangnam Severance Hospital in Seoul. Serum CEA levels were categorized into quartiles: Q1 (≤1.0 g/L), Q2 (1.1∼1.4 g/L), Q3 (1.5∼2.1 g/L), and Q4 (≥2.2 g/L). The odds ratio (OR) and 95% confidence interval (CI) for metabolic syndrome were calculated using multiple logistic regression analysis after adjusting for confounding factors across CEA quartiles. Results: The mean CEA levels were increased in people with obesity, high blood pressure, and high plasma glucose. Compared with the lowest CEA quartile, the OR (95% CI) for metabolic syndrome in the highest CEA quartile was 1.34 (1.03 to 1.73) after adjusting for age, cigarette smoking, alcohol intake, regular exercise, and leukocyte count. Conclusion: CEA was significantly related with metabolic syndrome in middle aged and elderly Korean females, and elevated CEA levels may be a surrogate marker for metabolic syndrome.