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Unconventional protein secretion - new insights into the pathogenesis and therapeutic targets of human diseases

Other Titles
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Authors
 Jiyoon Kim  ;  Heon Yung Gee  ;  Min Goo Lee 
Citation
 Journal of Cell Science, Vol.131(12), 2018 
Journal Title
 Journal of Cell Science 
ISSN
 0021-9533 
Issue Date
2018
Keywords
Human disease ; Leaderless protein ; Pathogenesis ; Therapeutic target ; Unconventional secretion
Abstract
Most secretory proteins travel through a well-documented conventional secretion pathway involving the endoplasmic reticulum (ER) and the Golgi complex. However, recently, it has been shown that a significant number of proteins reach the plasma membrane or extracellular space via unconventional routes. Unconventional protein secretion (UPS) can be divided into two types: (i) the extracellular secretion of cytosolic proteins that do not bear a signal peptide (i.e. leaderless proteins) and (ii) the cell-surface trafficking of signal-peptide-containing transmembrane proteins via a route that bypasses the Golgi. Understanding the UPS pathways is not only important for elucidating the mechanisms of intracellular trafficking pathways but also has important ramifications for human health, because many of the proteins that are unconventionally secreted by mammalian cells and microorganisms are associated with human diseases, ranging from common inflammatory diseases to the lethal genetic disease of cystic fibrosis. Therefore, it is timely and appropriate to summarize and analyze the mechanisms of UPS involvement in disease pathogenesis, as they may be of use for the development of new therapeutic approaches. In this Review, we discuss the intracellular trafficking pathways of UPS cargos, particularly those related to human diseases. We also outline the disease mechanisms and the therapeutic potentials of new strategies for treating UPS-associated diseases.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162672
Full Text
http://jcs.biologists.org/content/131/12/jcs213686
DOI
10.1242/jcs.213686
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
Yonsei Authors
이민구(Lee, Min Goo) ORCID logo https://orcid.org/0000-0001-7436-012X
지헌영(Gee, Heon Yung) ORCID logo https://orcid.org/0000-0002-8741-6177
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