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The relationship of insulin resistance estimated by triglyceride glucose index and coronary plaque characteristics

 Ki-Bum Won  ;  Yun Seok Kim  ;  Byoung Kwon Lee  ;  Ran Heo  ;  Donghee Han  ;  Ji Hyun Lee  ;  Sang-Eun Lee  ;  Ji Min Sung  ;  Iksung Cho  ;  Hyung-Bok Park  ;  In-Jeong Cho  ;  Hyuk-Jae Chang 
 Medicine, Vol.97(21) : e10726, 2018 
Journal Title
Issue Date
Adult ; Aged ; Biomarkers/blood ; Blood Glucose/*analysis ; Computed Tomography Angiography/*methods ; Coronary Artery Disease/*diagnostic imaging/epidemiology ; Coronary Vessels/pathology ; Female ; Humans ; Insulin Resistance/*physiology ; Male ; Middle Aged ; Atherosclerotic/diagnostic imaging Plaque ; Prevalence ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Triglycerides/*blood ; Vascular Calcification/diagnostic imaging/epidemiology
The triglyceride glucose (TyG) index is a useful surrogate marker for insulin resistance, which is an important risk factor for coronary artery disease (CAD). However, data on the relationship of the TyG index and coronary plaque characteristics are limited.This study included 2840 participants with near-normal renal function who underwent coronary computed tomography angiography. CAD was defined as the presence of any plaques, and obstructive CAD was defined as the presence of plaques with >/=50% stenosis. The relationship between the TyG index and noncalcified plaque (NCP), calcified or mixed plaque (CMP), and coronary artery calcium score (CACS) was evaluated.All participants were stratified into 4 groups based on the quartiles of the TyG index. The prevalence of CAD and obstructive CAD significantly increased with increasing quartiles. The risk for NCP and obstructive NCP was not different among all groups. However, compared with group I (lowest quartile), the risk for CMP was higher in groups III (odds ratio [OR]: 1.438) and IV (highest quartile) (OR: 1.895) (P < .05), and that for obstructive CMP was higher in groups II (OR: 1.469), III (OR: 1.595), and IV (OR: 2.168) (P < .05). Multivariate regression analysis showed that the TyG index was associated with an increased risk for CAD (OR: 1.700), obstructive CAD (OR: 1.692), and CACS >400 (OR: 1.448) (P < .05).The TyG index was independently associated with the presence and severity of CAD due to an increased risk for CMP.
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5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
성지민(Sung, Ji Min)
이병권(Lee, Byoung Kwon) ORCID logo https://orcid.org/0000-0001-9259-2776
이상은(Lee, Sang Eun) ORCID logo https://orcid.org/0000-0001-6645-4038
장혁재(Chang, Hyuck Jae) ORCID logo https://orcid.org/0000-0002-6139-7545
조인정(Cho, In Jeong)
한동희(Han, Donghee)
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