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The relationship of insulin resistance estimated by triglyceride glucose index and coronary plaque characteristics

DC FieldValueLanguage
dc.contributor.author성지민-
dc.contributor.author장혁재-
dc.contributor.author조인정-
dc.contributor.author한동희-
dc.contributor.author이상은-
dc.contributor.author이병권-
dc.date.accessioned2018-08-28T17:27:26Z-
dc.date.available2018-08-28T17:27:26Z-
dc.date.issued2018-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162633-
dc.description.abstractThe triglyceride glucose (TyG) index is a useful surrogate marker for insulin resistance, which is an important risk factor for coronary artery disease (CAD). However, data on the relationship of the TyG index and coronary plaque characteristics are limited.This study included 2840 participants with near-normal renal function who underwent coronary computed tomography angiography. CAD was defined as the presence of any plaques, and obstructive CAD was defined as the presence of plaques with >/=50% stenosis. The relationship between the TyG index and noncalcified plaque (NCP), calcified or mixed plaque (CMP), and coronary artery calcium score (CACS) was evaluated.All participants were stratified into 4 groups based on the quartiles of the TyG index. The prevalence of CAD and obstructive CAD significantly increased with increasing quartiles. The risk for NCP and obstructive NCP was not different among all groups. However, compared with group I (lowest quartile), the risk for CMP was higher in groups III (odds ratio [OR]: 1.438) and IV (highest quartile) (OR: 1.895) (P < .05), and that for obstructive CMP was higher in groups II (OR: 1.469), III (OR: 1.595), and IV (OR: 2.168) (P < .05). Multivariate regression analysis showed that the TyG index was associated with an increased risk for CAD (OR: 1.700), obstructive CAD (OR: 1.692), and CACS >400 (OR: 1.448) (P < .05).The TyG index was independently associated with the presence and severity of CAD due to an increased risk for CMP.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMedicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBlood Glucose/*analysis-
dc.subject.MESHComputed Tomography Angiography/*methods-
dc.subject.MESHCoronary Artery Disease/*diagnostic imaging/epidemiology-
dc.subject.MESHCoronary Vessels/pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance/*physiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHAtherosclerotic/diagnostic imaging Plaque-
dc.subject.MESHPrevalence-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHTriglycerides/*blood-
dc.subject.MESHVascular Calcification/diagnostic imaging/epidemiology-
dc.titleThe relationship of insulin resistance estimated by triglyceride glucose index and coronary plaque characteristics-
dc.typeArticle-
dc.contributor.collegeResearch Institutes-
dc.contributor.departmentYonsei Cardiovascular Research Institute-
dc.contributor.googleauthorKi-Bum Won-
dc.contributor.googleauthorYun Seok Kim-
dc.contributor.googleauthorByoung Kwon Lee-
dc.contributor.googleauthorRan Heo-
dc.contributor.googleauthorDonghee Han-
dc.contributor.googleauthorJi Hyun Lee-
dc.contributor.googleauthorSang-Eun Lee-
dc.contributor.googleauthorJi Min Sung-
dc.contributor.googleauthorIksung Cho-
dc.contributor.googleauthorHyung-Bok Park-
dc.contributor.googleauthorIn-Jeong Cho-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.identifier.doi10.1097/md.0000000000010726-
dc.contributor.localIdA01955-
dc.contributor.localIdA03490-
dc.contributor.localIdA03892-
dc.contributor.localIdA04811-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid29794749-
dc.contributor.alternativeNameSung, Ji Min-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.alternativeNameCho, In Jeong-
dc.contributor.alternativeNameHan, Donghee-
dc.contributor.affiliatedAuthorSung, Ji Min-
dc.contributor.affiliatedAuthorChang, Hyuck Jae-
dc.contributor.affiliatedAuthorCho, In Jeong-
dc.contributor.affiliatedAuthorHan, Donghee-
dc.citation.volume97-
dc.citation.number21-
dc.citation.startPagee10726-
dc.identifier.bibliographicCitationMedicine, Vol.97(21) : e10726, 2018-
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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