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Bone Regeneration of Peri-Implant Defects Using a Collagen Membrane as a Carrier for Recombinant Human Bone Morphogenetic Protein-2

 Yoo-Kyung Sun  ;  Jae-Kook Cha  ;  Daniel Stefan Thoma  ;  So-Ra Yoon  ;  Jung-Seok Lee  ;  Seong-Ho Choi  ;  Ui-Won Jung 
 BIOMED RESEARCH INTERNATIONAL, Vol.2018 : 5437361, 2018 
Journal Title
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This study is designed to determine the effect of collagen membrane (CM) soaked with bone morphogenetic protein-2 (rhBMP-2) for the treatment of peri-implant dehiscence defects. Material and Methods.Three treatment groups were allocated at each defect in 5 dogs: (i) collagenated synthetic bone (OC) and CM soaked with rhBMP-2 (BMP group), (ii) OC and CM soaked with saline (nonBMP group), and (iii) no further treatment (control group). Titanium pins were used to stabilize the membranes in two dogs. Radiographic and histomorphometric analyses were performed 4 weeks later. Results.The median augmented volumes were 4.27 mm3, 6.24 mm3, and 2.75mm3 in the BMP, nonBMP, and control groups, respectively; the corresponding median first bone-toimplant contact (fBIC) distances were 3.25 mm, 3.08 mm, and 2.56 mm (𝑃 > 0.05). The placement of pins (with the BMP and nonBMP groups pooled) significantly improved bone regeneration: the augmented volumes were 17.60 mm3 with pins and 3.68 mm3 without pins (𝑃 = 0.024), with corresponding fBIC distances of 2.25 mm and 3.31 mm, respectively (𝑃 < 0.001). Conclusions. The addition of rhBMP-2 to CM failed to improve bone regeneration of peri-implant dehiscence defects compared to using an unsoaked CM after 4 weeks. However, the stabilization of CMs using pins positively influenced the outcomes.
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2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Sun, Yoo Kyung(선유경)
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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