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Bone Regeneration of Peri-Implant Defects Using a Collagen Membrane as a Carrier for Recombinant Human Bone Morphogenetic Protein-2

Authors
 Yoo-Kyung Sun  ;  Jae-Kook Cha  ;  Daniel Stefan Thoma  ;  So-Ra Yoon  ;  Jung-Seok Lee  ;  Seong-Ho Choi  ;  Ui-Won Jung 
Citation
 BioMed Research International, Vol.2018 : 5437361, 2018 
Journal Title
 BioMed Research International 
ISSN
 2314-6133 
Issue Date
2018
Abstract
This study is designed to determine the effect of collagen membrane (CM) soaked with bone morphogenetic protein-2 (rhBMP-2) for the treatment of peri-implant dehiscence defects. Material and Methods.Three treatment groups were allocated at each defect in 5 dogs: (i) collagenated synthetic bone (OC) and CM soaked with rhBMP-2 (BMP group), (ii) OC and CM soaked with saline (nonBMP group), and (iii) no further treatment (control group). Titanium pins were used to stabilize the membranes in two dogs. Radiographic and histomorphometric analyses were performed 4 weeks later. Results.The median augmented volumes were 4.27 mm3, 6.24 mm3, and 2.75mm3 in the BMP, nonBMP, and control groups, respectively; the corresponding median first bone-toimplant contact (fBIC) distances were 3.25 mm, 3.08 mm, and 2.56 mm (𝑃 > 0.05). The placement of pins (with the BMP and nonBMP groups pooled) significantly improved bone regeneration: the augmented volumes were 17.60 mm3 with pins and 3.68 mm3 without pins (𝑃 = 0.024), with corresponding fBIC distances of 2.25 mm and 3.31 mm, respectively (𝑃 < 0.001). Conclusions. The addition of rhBMP-2 to CM failed to improve bone regeneration of peri-implant dehiscence defects compared to using an unsoaked CM after 4 weeks. However, the stabilization of CMs using pins positively influenced the outcomes.
Files in This Item:
T201801907.pdf Download
DOI
10.1155/2018/5437361
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실)
Yonsei Authors
선유경(Sun, Yoo Kyung)
이중석(Lee, Jung Seok) ORCID logo https://orcid.org/0000-0003-1276-5978
정의원(Jung, Ui Won) ORCID logo https://orcid.org/0000-0001-6371-4172
차재국(Cha, Jae Kook) ORCID logo https://orcid.org/0000-0001-6817-9834
최성호(Choi, Seong Ho) ORCID logo https://orcid.org/0000-0001-6704-6124
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162551
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