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The Schwann Cell as an Active Synaptic Partner

Authors
 Sujin Hyung  ;  Kyuhwan Jung  ;  Sung-Rae Cho  ;  Noo Li Jeon 
Citation
 Chemphyschem, Vol.19(10) : 1123-1127, 2018 
Journal Title
 Chemphyschem 
ISSN
 1439-4235 
Issue Date
2018
MeSH
Animals ; Humans ; Schwann Cells/cytology/*metabolism ; Synapses/*metabolism
Keywords
Ca2+ signal ; gliotransmitter ; neuron-glia interaction ; schwann cell ; synapse
Abstract
The schwann cells of the peripheral nervous system are indispensable for the formation, maintenance, and modulation of synapses over the life cycle. They not only recognize neuron-glia signaling molecules, but also secrete gliotransmitters. Through these processes, they regulate neuronal excitability and thus the release of neurotransmitters from the nerve terminal at the neuromuscular junction. Gliotransmitters strongly affect nerve communication, and their secretion is mainly triggered by synchronized Ca(2+) signaling, implicating Ca(2+) waves in synapse function. Reciprocally, neurotransmitters released during synaptic activity can evoke increases in intracellular Ca(2+) levels. A reconsideration of the interplay between the two main types of cells in the nervous system is due, as the concept of nervous system activity comprising only neuron-neuron and neuron-muscle action has become untenable. A more precise understanding of the roles of schwann cells in nerve-muscle signaling is required.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/cphc.201701299
DOI
10.1002/cphc.201701299
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실)
Yonsei Authors
조성래(Cho, Sung-Rae) ORCID logo https://orcid.org/0000-0003-1429-2684
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162545
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