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Changes in bone mineral density and bone turnover markers during treatment with teriparatide in pregnancy- and lactation-associated osteoporosis

Authors
 Namki Hong  ;  Jo Eun Kim  ;  Su Jin Lee  ;  Se Hwa Kim  ;  Yumie Rhee 
Citation
 Clinical Endocrinology, Vol.88(5) : 652-658, 2018 
Journal Title
 Clinical Endocrinology 
ISSN
 0300-0664 
Issue Date
2018
Keywords
idiopathic osteoporosis ; pregnancy-associated osteoporosis ; premenopausal women ; recombinant human parathyroid hormone (1-34) ; vertebral fracture
Abstract
CONTEXT: Teriparatide (TPTD) therapy has been proposed as a potential treatment strategy in severe cases of pregnancy- and lactation-associated osteoporosis (PLO) characterized by the occurrence of fragility fractures in the third trimester or early postpartum. OBJECTIVE: To investigate the changes in bone mineral density (BMD) and bone turnover markers in patients with PLO with and without TPTD treatment. DESIGN: Retrospective cohort study. PATIENTS: Thirty-two patients with PLO who presented with multiple vertebral fractures to a tertiary institution between 2007 and 2015 were included. MEASUREMENTS: Changes in BMD at the lumbar spine (LSBMD) and proximal femur after 12 months of daily subcutaneous injections of 20 mug TPTD (n = 27) were assessed. Subjects who rejected the TPTD treatment were used as controls (n = 5). RESULTS: LSBMD increased in both subjects treated with TPTD and controls, with greater increases in the TPTD group (15.5 +/- 6.6% vs 7.5 +/- 7.1%, P = .020) after adjustment for age and baseline LSBMD. During follow-up, serum levels of osteocalcin (OCN) and C-telopeptide of type I collagen (CTX) increased significantly in the TPTD group. In multivariate linear regression models, TPTD treatment (adjusted beta = 7.92, P = .032) and younger age (adjusted beta = 1.06, P = .046), but not baseline LSBMD, body mass index, serum OCN level and CTX level, were independently associated with greater increases in LSBMD. CONCLUSIONS: In patients with PLO, LSBMD at 12 months increased in both the TPTD-treated and control groups. TPTD treatment and younger age were associated with greater increases in LSMBD irrespective of baseline LSBMD.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13557
DOI
10.1111/cen.13557
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
이수진(Lee, Su Jin) ORCID logo https://orcid.org/0000-0002-7325-2538
이유미(Rhee, Yumie) ORCID logo https://orcid.org/0000-0003-4227-5638
홍남기(Hong, Nam Ki) ORCID logo https://orcid.org/0000-0002-8246-1956
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162540
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