Cited 51 times in
Changes in bone mineral density and bone turnover markers during treatment with teriparatide in pregnancy- and lactation-associated osteoporosis
DC Field | Value | Language |
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dc.contributor.author | 이수진 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 홍남기 | - |
dc.date.accessioned | 2018-08-28T17:22:44Z | - |
dc.date.available | 2018-08-28T17:22:44Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162540 | - |
dc.description.abstract | CONTEXT: Teriparatide (TPTD) therapy has been proposed as a potential treatment strategy in severe cases of pregnancy- and lactation-associated osteoporosis (PLO) characterized by the occurrence of fragility fractures in the third trimester or early postpartum. OBJECTIVE: To investigate the changes in bone mineral density (BMD) and bone turnover markers in patients with PLO with and without TPTD treatment. DESIGN: Retrospective cohort study. PATIENTS: Thirty-two patients with PLO who presented with multiple vertebral fractures to a tertiary institution between 2007 and 2015 were included. MEASUREMENTS: Changes in BMD at the lumbar spine (LSBMD) and proximal femur after 12 months of daily subcutaneous injections of 20 mug TPTD (n = 27) were assessed. Subjects who rejected the TPTD treatment were used as controls (n = 5). RESULTS: LSBMD increased in both subjects treated with TPTD and controls, with greater increases in the TPTD group (15.5 +/- 6.6% vs 7.5 +/- 7.1%, P = .020) after adjustment for age and baseline LSBMD. During follow-up, serum levels of osteocalcin (OCN) and C-telopeptide of type I collagen (CTX) increased significantly in the TPTD group. In multivariate linear regression models, TPTD treatment (adjusted beta = 7.92, P = .032) and younger age (adjusted beta = 1.06, P = .046), but not baseline LSBMD, body mass index, serum OCN level and CTX level, were independently associated with greater increases in LSBMD. CONCLUSIONS: In patients with PLO, LSBMD at 12 months increased in both the TPTD-treated and control groups. TPTD treatment and younger age were associated with greater increases in LSMBD irrespective of baseline LSBMD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Publishing | - |
dc.relation.isPartOf | CLINICAL ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Changes in bone mineral density and bone turnover markers during treatment with teriparatide in pregnancy- and lactation-associated osteoporosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Jo Eun Kim | - |
dc.contributor.googleauthor | Su Jin Lee | - |
dc.contributor.googleauthor | Se Hwa Kim | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.identifier.doi | 10.1111/cen.13557 | - |
dc.contributor.localId | A02894 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A04388 | - |
dc.relation.journalcode | J00571 | - |
dc.identifier.eissn | 1365-2265 | - |
dc.identifier.pmid | 29389010 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13557 | - |
dc.subject.keyword | idiopathic osteoporosis | - |
dc.subject.keyword | pregnancy-associated osteoporosis | - |
dc.subject.keyword | premenopausal women | - |
dc.subject.keyword | recombinant human parathyroid hormone (1-34) | - |
dc.subject.keyword | vertebral fracture | - |
dc.contributor.alternativeName | Lee, Su Jin | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Hong, Nam Ki | - |
dc.contributor.affiliatedAuthor | Lee, Su Jin | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Hong, Namki | - |
dc.citation.volume | 88 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 652 | - |
dc.citation.endPage | 658 | - |
dc.identifier.bibliographicCitation | CLINICAL ENDOCRINOLOGY, Vol.88(5) : 652-658, 2018 | - |
dc.identifier.rimsid | 60121 | - |
dc.type.rims | ART | - |
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