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Can Biannual Ultrasound Surveillance Detect Smaller Second Cancers or Detect Cancers Earlier in Patients with Breast Cancer History?

Authors
 Jai Kyung You  ;  Mi Kyung Song  ;  Min Jung Kim  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Ji Hyun Youk  ;  Jung Hyun Yoon  ;  Vivian Youngjean Park  ;  Seho Park  ;  Seung Il Kim  ;  Byeong-Woo Park 
Citation
 Ultrasound in Medicine and Biology, Vol.44(7) : 1355-1363, 2018 
Journal Title
 Ultrasound in Medicine and Biology 
ISSN
 0301-5629 
Issue Date
2018
Keywords
Breast cancer ; Recurrence ; Surveillance ; Ultrasound
Abstract
The aim of the work described here was to evaluate whether surveillance with biannual ultrasound (US) plus annual mammography (biannual group) for women with a history of breast cancer surgery results in earlier detection or in the detection of smaller second cancers than annual US plus mammography (annual group). Additionally, we compared the prevalence of distant metastases or palpable second cancers between the biannual and annual groups. The institutional review board of our institution approved this retrospective study, and patient consent was waived. Between January 2011 and December 2012, we retrospectively reviewed the clinical and imaging follow-up of 3023 patients with mammographic and US surveillance after breast cancer surgery to assess second cancers detected by local surveillance (locoregional recurrence, contralateral breast cancer or distant metastasis). The biannual and annual groups were divided with respect to the mean surveillance interval and compared with respect to clinicopathologic findings. Multivariable logistic regression with propensity score methods was used to examine the effect of the type of surveillance on outcomes. As for the size of the second cancer, no difference was seen between the biannual and annual groups (12.8 +/- 6.6 mm vs. 14.1 +/- 7.1 mm, p = 0.461); neither was there a significant difference between the groups in the presence of symptoms at the time of diagnosis of the second cancer (17.0% [8/47] vs. 10% [2/20], p = 0.711). Regardless of detection by local surveillance, the prevalence of distant metastases did not differ between the two groups (1.1% [27/2370] vs. 1.0% [7/653], p = 0.88) on univariate or multivariate analysis. The results of our retrospective study indicate that second cancers detected by biannual US surveillance in patients with a history of breast cancer surgery are not smaller and do not occur earlier than those detected by annual US surveillance. However, a randomized controlled study is required to verify these results before they can be generalized to clinical practice.
Full Text
https://www.sciencedirect.com/science/article/pii/S0301562918300851
DOI
10.1016/j.ultrasmedbio.2018.02.019
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
김민정(Kim, Min Jung) ORCID logo https://orcid.org/0000-0003-4949-1237
김승일(Kim, Seung Il)
김은경(Kim, Eun-Kyung) ORCID logo https://orcid.org/0000-0002-3368-5013
문희정(Moon, Hee Jung) ORCID logo https://orcid.org/0000-0002-5643-5885
박병우(Park, Byeong Woo) ORCID logo https://orcid.org/0000-0003-1353-2607
박세호(Park, Se Ho) ORCID logo https://orcid.org/0000-0001-8089-2755
박영진(Park, Vivian Youngjean) ORCID logo https://orcid.org/0000-0002-5135-4058
송미경(Song, Mi Kyung)
육지현(Youk, Ji Hyun) ORCID logo https://orcid.org/0000-0002-7787-780X
윤정현(Yoon, Jung Hyun) ORCID logo https://orcid.org/0000-0002-2100-3513
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162478
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