0 57

Cited 0 times in

Real-time dynamics of neutrophil clustering in response to phototoxicity-induced cell death and tissue damage in mouse ear dermis

Authors
 Sang A Park  ;  Young Ho Choe  ;  Eunji Park  ;  Young-Min Hyun 
Citation
 Cell Adhesion & Migration, Vol.0 : 1-8, 2018 
Journal Title
 Cell Adhesion & Migration 
ISSN
 1933-6918 
Issue Date
2018
Keywords
Neutrophil ; intravital imaging ; migration ; phototoxicity ; two-photon microscopy
Abstract
Neutrophils are highly motile innate immune cells; they actively migrate in response to inflammatory signals. Using two-photon intravital microscopy, we discovered that neutrophils form stable clusters upon phototoxicity at a certain threshold. Without significant damage to the collagen structure of mouse dermis, neutrophils aggregated together with nearby neutrophils. Surprisingly, this in situ neutrophil clustering resulted in rigorous changes of migratory direction. The density of residing neutrophils was also a critical factor affecting clustering. Additionally, we found that the triggering point of neutrophil aggregation was correlated with the structure of the extracellular matrix in the ear dermis, where autofluorescence was strongly observed. This swarming behavior of neutrophils may reflect an unknown communication mechanism of neutrophils during migration under sterile injury.
Full Text
https://www.tandfonline.com/doi/full/10.1080/19336918.2018.1471322
DOI
10.1080/19336918.2018.1471322
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실)
Yonsei Authors
현영민(Hyun, Young-Min) ORCID logo https://orcid.org/0000-0002-0567-2039
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162473
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse